The purpose of this study was to investigate the effects of size and type of incorporated model molecules on the polymer degradation and release profile from thermosensitive triblock copolymer based controlled delivery systems. In vitro release of the incorporated molecules demonstrated slow release for risperidone (molecular weight (Mw) = 410.48 Da; partition coefficient (Ko/w) = 3.49), while ...

The inositol-containing phosphatides of soy beans have been the subject of a number of investigations (l-7) since 1939 when Klenk and Sakai (8) first reported the presence of inositol in soy bean phosphatides. Previous work at the Northern Regional Research Laboratory (3) has shown that the alcohol-insoluble portion of soy bean phosphatides can be separated into two inositol-containing fraction...

E. T. Petersen, K. C. van de Ven, I. Zimine, X. Golay Neuroradiology, National Neuroscience Institute, Singapore, Singapore, Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, Singapore Bioimaging Consortium, ASTAR, Singapore, Singapore INTRODUCTION: Perfusion is vital for the homeostasis and thereby survival of an organ and as such is a very important physiolog...

Measurements of diffusion and partitioning of solutes having molecular weights ranging 180-66 000 in PVA gel membranes with various crosslinking degree were carried out. With increasing solute size or decreasing number of average molecular weight between crosslinks of the membranes, both the solute permeability and partition coefficient decreased. In spite of similar solute sizes, the more hydr...

Aqueous solubility and partition coefficient are important physical properties of small molecules. Accurate theoretical prediction of aqueous solubility and partition coefficient plays an important role in drug design and discovery. The prediction accuracy depends crucially on molecular descriptors which are typically derived from theoretical understanding of the chemistry and physics of small ...

AIM To examine the in-vitro transport route of tetramethylpyrazine (TMP) across porcine buccal mucosa and to investigate the effects of drug concentration, pH in donor chamber, and 1-octanol/buffer partition coefficient on transbuccal permeation. METHODS In-vitro permeation of TMP through porcine buccal mucosa was studied by using in-line flow through diffusion cells at 37 . The permeability ...