Strength training has, in recent years, been shown to be beneficial for people with Parkinson disease and multiple sclerosis. Consensus regarding its utility for these disorders nevertheless remains contentious among healthcare professionals. Greater clarity is required, especially in regards to the type and magnitude of effects as well as the response differences to strength training between i...

BACKGROUND AND PURPOSE Both diffusion tensor imaging and the apparent transverse relaxation rate have shown promise in differentiating Parkinson disease from atypical parkinsonism (particularly multiple system atrophy and progressive supranuclear palsy). The objective of the study was to assess the ability of DTI, the apparent transverse relaxation rate, and their combination for differentiatin...

ôbjective: previous studies reported that individuals with parkinson’s disease are less likely to have smoking history and it seems that nicotine has a neuroprotective effect. the authors have conducted a case-control retrospective study to determine if there is an association between cigarette smoking and parkinson’s disease. methods: ïn a matched case-control study, 92 individuals with parkin...

background & aim: parkinson's disease (pd) can be created with loss of dopaminergic substantial nigra neurons which is widely associated with oxidative stress and reduced glutathione (gsh), as the most important and abundant thiol in tissues and one of the antioxidant defense, is one of the earliest biochemical events related to parkinson's and consumption of antioxidants has a protective e...

OBJECTIVE To evaluate the socio-demographic and clinical feature of patients with Parkinson`s disease, their health-related quality of life (HRQoL), and the relationship between these. METHODS This cross-sectional study was conducted in Istanbul University Cerrahpasa Medical Faculty Hospital, and Ministry of Health, Taksim and Haseki Education and Research Hospitals in Istanbul, Turkey. The s...

In this Commentary, I describe the events that led from an NINDS-sponsored Workshop on Parkinson Disease Research in 1995, where I was asked to speak about the genetics of Parkinson disease, to the identification a mere two years later of a mutation in alpha-synuclein as the cause of autosomal dominant Parkinson disease in the Contursi kindred. I review the steps we took to first map and then f...

BACKGROUND Pedunculopontine nucleus (PPN) stimulation is a novel therapy for Parkinson disease. However, controversies remain regarding the clinical application of this new therapy, including patient selection, electrode positioning, and how best to assess outcomes. OBJECTIVE To clarify the clinical application of PPN stimulation in Parkinson disease. METHODS Five consecutive patients with ...

The induction of ventricular tachycardia by ventricular stimulation was investigated in 46 patients with isolated Wolff-Parkinson-White syndrome (10 concealed) and 36 control patients with normal electrocardiograms and conduction systems. None of those studied had spontaneous ventricular arrhythmias or myocardial or valve disease. Single and double ventricular extrastimuli were delivered at 3 c...

BACKGROUND The detection of hyperechogenicity of the substantia nigra using trans cranial sonography can be predictive of the diagnosis of Parkinson Disease. AIM To report an experience with transcranial sonography for the diagnosis of Parkinson disease. Material ana METHODS One hundred sixteen patients with movement disorders were subjected to a transcranial sonography to detect the presen...