background it has been proposed that reactive oxygen species (ros) is involved in the pathogenesis of various diseases. paraoxonase, a high-density lipoprotein associated enzyme, prevents low-density lipoproteins from oxidation. objectives the aim of the present study was to investigate the serum activities of paraoxonase-1 (pon-1), and aryleterase (are) as well as total antioxidant capacity (t...

Background: Cancer has the highest disease-related mortality rate in Iran. Reduced activity of paraoxonase reported in patients with cancer may be due to a reduction in its antioxidant properties and a subsequent increased risk of developing cancer. We aimed to assess antioxidant and oxidative status in patients with cancer through measuring the activity of PON1 as an antioxidant enzyme and det...

Background: Recent studies have shown that non-alcoholic fatty liver disease (NAFLD) is associated with increased carotid intima-media thickness as a reliable marker of early atherosclerosis, but possible direct relationships between NAFLD and carotid artery atherosclerosis is unknown. Therefore, the aim of this study was to investigate serum paraoxonase and arylesterase activities (PON1) along...

Coronary Artery Disease is the major cause of mortality and morbidity worldwide. Serum paraoxonase is a high density lipoprotein (HDL)-bound enzyme exhibiting antiatherogenic properties. Oxidative stress plays the major role in the atherosclerotic process. In the present case control study, serum paraoxonase activity and oxidative stress were monitored in 100 patients with AMI and 50 age and se...

background: cancer has the highest disease-related mortality rate in iran. reduced activity of paraoxonase reported in patients with cancer may be due to a reduction in its antioxidant properties and a subsequent increased risk of developing cancer. we aimed to assess antioxidant and oxidative status in patients with cancer through measuring the activity of pon1 as an antioxidant enzyme and det...

BACKGROUND The southern United States (excluding Florida) has the highest age-adjusted rate of cardiovascular disease (CVD) in the country, with African Americans having a higher prevalence of CVD than Caucasians. Paraoxonase-1 (PON1), an enzyme associated with high-density lipoprotein particles, participates both in the hydrolysis of oxidized lipids (thus protecting against atherosclerosis) an...

BACKGROUND Paraoxonase 1 (PON1) activity and von Willebrand factor (VWF) release are associated with lesion initiation in atherosclerosis. Diabetes can complicate coronary artery disease (CAD) due to the production of advanced glycation end products. This study evaluated PON1 activity and VWF levels in non-post-acute coronary syndrome, stable CAD (SCAD) patients without diabetes. MATERIAL/MET...

Cardiac death from atherosclerosis is common in hemodialysis patients. Human serum paraoxonase (PON1), an esterase, is associated with high-density lipoprotein and inhibits the susceptibility to oxidization of low-density lipoprotein (LDL). The PON1 genetic polymorphisms of 192 Gln/Arg and 55 Leu/Met in the amino acid sequence are partly involved in the PON1 enzyme activity. We investigated the...