BACKGROUND We previously examined transverse propagation of action potentials between 2 and 3 parallel chain of cardiac muscle cells (CMC) simulated using the PSpice program. The present study was done to examine transverse propagation between 5 parallel chains in an expanded model of CMC and smooth muscle cells (SMC). METHODS Excitation was transmitted from cell to cell along a strand of 5 c...

in this research work, a novel parallel manipulator with high positioning and orienting rate is introduced. this mechanism has two rotational and one translational degree of freedom. kinematics and jacobian analysis are investigated. moreover, workspace analysis and optimization has been performed by using genetic algorithm toolbox in matlab software. because of decreasing moving elements, it i...

In parallel with the pediatric obesity epidemic, the incidence of impaired glucose tolerance and type 2 diabetes has increased among youth. Insulin resistance is thought to be central to the pathophysiology of these obesity-related disorders. A growing body of literature suggests that exercise may ameliorate insulin resistance and thus potentially reduce the long-term diabetes risk in overweigh...

Objective: Diabetes is a common endocrine disorder caused by deficiency of insulin secretion or insulin resistant. nowadays, in addition to trying to find a safe way to control diabetes, find the low side effect way is important. This study was designed to find the effect of Urtica dioica extract on glycemic control and insulin resistance in patients with type 2 diabetes. Materials and Methods...

one of the most important duties of government in public health sector is to provide secured sources for medicines supply. there are some regulations for domestic pharmaceutical industry. in addition, there is a discipline for importing medicine to be ensured about their claimed characteristics. in medicines registration process, moh (fdo in iran) assess ‘safety’, ‘quality’ and ‘efficacy’ of me...

Antibiotic resistance often evolves by mutations at conserved sites in essential genes, resulting in parallel molecular evolution between divergent bacterial strains and species. Whether these resistance mutations are having parallel effects on fitness across bacterial taxa, however, is unclear. This is an important point to address, because the fitness effects of resistance mutations play a ke...

Due to the broad use of parallel-connected cells across a wide variety applications, it is essential understand current distribution between them. Variations in resistance, temperature and capacity can lead an inhomogeneous have deleterious influence on ageing safety. It therefore crucial investigate within such systems. Many researchers designed distinct test-benches measure distribution. In a...

OBJECTIVES Biocides are widely used to prevent infection. We aimed to determine whether exposure of Salmonella to various biocides could act as a driver of antibiotic resistance. METHODS Salmonella enterica serovar Typhimurium was exposed to four biocides with differing modes of action. Antibiotic-resistant mutants were selected during exposure to all biocides and characterized phenotypically...