We developed an automated colorimetric method for the quantitative determination of p-aminophenol with a Cobas Mira analyzer. The procedure can be used for the biological monitoring of human exposure to aniline. An absorbed aniline dose is extensively oxidized to p-aminophenol, which is excreted in urine mainly as glucurono- and sulfo- conjugates. After enzymatic hydrolysis, we reacted the free...

By the late 1800s, both phenacetin and acetanilide were used as analgesics and antipyretics, but their acceptance was limited by significant side effects including methemoglobinemia. N-acetyl-p-aminophenol (APAP) is a major metabolite of phenacetin and acetanilide, and is responsible for, both analgesia and antipyresis. APAP was synthesized in 1878 and has a low risk of causing methemoglobinemi...

Background: Paracetamol (acetaminophen, N-acetyl-para-aminophenol) is a well-known antipyretic and analgesic drug. Hypersensitivity reactions to paracetamol are rare. However, we report seven cases of anaphylaxis to paracetamol and a review of the literature. Procedure: Between January 1999 and May 2012, we diagnosed seven cases of anaphylaxis to paracetamol in our Allergy Department of Hospita...

A simple, rapid, and specific spectrophotometric method was developed for the determination of paracetamol in pure form drug formulations. The depended on hydrolysis to p-aminophenol, which, oxidized under effect dissolved oxygen benzoquinoneimine. In alkaline medium, benzoquinoneimine reacts with Methyldopa produce a high stabile indophenol dye. absorbance measured at 580 nm, molar absorptivit...

N-(2-methoxyphenyl)hydroxylamine is a human metabolite of the industrial and environmental pollutants and bladder carcinogens 2-methoxyaniline (o-anisidine) and 2-methoxynitrobenzene (o-nitroanisole). Here, we investigated the ability of hepatic microsomes from rat and rabbit to metabolize this reactive compound. We found that N-(2-methoxyphenyl)hydroxylamine is metabolized by microsomes of bot...

In view of the role ascribed to the peroxidatic activity of degradation products of cytochrome c (cyt c) in the processes of apoptosis, we investigate the catalytic potential of heme and of the cyt c derived heme peptide MP-11 to catalyse the cathodic reduction of hydrogen peroxide and to oxidize aromatic compounds. In order to check whether cyt c has an enzymatic activity in the native state w...

Two types of enantioselective [2 + 2 + 2] cycloadditions of triynes using chiral rhodium catalysts are disclosed. The intramolecular reaction of ortho-aminophenol-tethered triynes provides chiral tripodal compounds. Consecutive interand intramolecular reactions of ortho-phenylene-tethered triynes provide chiral tetraphenylenes.

para-veterinarians are professionals in having a liaise between veterinary doctors and livestock owners beside their ability to achieve some of the veterinarians activity such as collecting information about sick animals, using thermometer, using needles and syringes, calculating, diluting and using antiseptic, knowledge about live and inactive vaccines, oral treatment of animals, herbal medici...