It is over 20 years since the inaugural deep inferior epigastric perforator (DIEP) flap breast reconstruction. We review the type of flap utilized and indications in 2,850 microvascular breast reconstruction over the subsequent 20 years in the senior author's practice (Robert J. Allen). Data were extracted from a personal logbook of all microsurgical free flap breast reconstructions performed b...

Eukaryotic Okazaki fragments are initiated by a RNA/DNA primer, which is removed before the fragments are joined. Polymerase delta displaces the primer into a flap for processing. Dna2 nuclease/helicase and flap endonuclease 1 (FEN1) are proposed to cleave the flap. The single-stranded DNA-binding protein, replication protein A (RPA), governs cleavage activity. Flap-bound RPA inhibits FEN1. Thi...

case presentation a 43-year-old man was referred to our institution for a severe aortic regurgitation and an ascending aorta enlargement associated with a relapsing sub-aortic membrane, which had been treated in his childhood. he underwent a redo ascending aorta replacement and an aortic valve replacement (mechanical prosthesis) along with a resection of the relapsing sub-valvular membrane. som...

BACKGROUND The purpose of this study was to compare postoperative morbidities and functional outcomes of pectoralis major myocutaneous (PMMC) flap and cutaneous free flap reconstruction approaches in hypopharyngeal squamous cell carcinoma patients. METHODS We retrospectively reviewed records from 99 patients who underwent hypopharyngeal reconstruction with a cutaneous free flap (n=85) or PMMC...

Rectangular flaps on the rat or mouse dorsum are frequently used for flap survival elongation research. However, since rectangular flaps are purely random, the survival rate varies among individuals. A reliable animal flap model with low individual variation is desirable for flap survival research, especially in the angiogenic field. We investigated the survival rate of paired flaps in the rat ...

Dna2 is a nuclease/helicase with proposed roles in DNA replication, double-strand break repair and telomere maintenance. For each role Dna2 is proposed to process DNA substrates with a 50-flap. To date, however, Dna2 has not revealed a preference for binding or cleavage of flaps over single-stranded DNA. Using DNA binding competition assays we found that Dna2 has substrate structure specificity...

Achieving adequate coverage of soft tissue defects located on the lower third of the legs and feet is challenging for reconstructive surgeons. Fasciocutaneous flaps can be used to meet this challenge. Two common fasciocutaneous flaps used in this context are the reverse sural flap and lateral supramalleolar flap (LSMF). Plastic and reconstructive surgeons are relatively unfamiliar with the seco...

I thank the Committee on Safety of Medicines for permission to report these cases and the doctors who originally submitted the reports for providing further clinical details. I O'Brien WM, Bagbv GF. Rare adverse reactions to non-steroidal antiinflammatory drugs. J Rheumatol 1985;12:13-20. 2 Flint KC, Johnson NM. Pulmonary eosinophilia associated with naproxen therapy. 7 R Soc Med 1987;80:120-1....

We have extended the study of Kuramoto model with additive Gaussian noise running on KKI-18 large human connectome graph. determined dynamical behavior this by solving it numerically in an assumed homeostatic state, below synchronization crossover point we previously. The de-synchronization duration distributions exhibit power-law tails, characterized exponent range 1.1<τt<2, overlapping vivo b...

The design of circulation control (CC) dual radius flap systems were investigated to characterize the parameters that make up the flap surface to offer further knowledge into the CC field of study. Multiple dual radius flap geometries, along with variants, were developed by varying specific flap parameters from a baseline configuration that had previously developed. The aerodynamics of the diff...