Liposomal pegylated doxorubicin is an encapsulation form of doxorubicin, with an improved pharmacokinetic profile and the ability to selectively accumulate into tumor tissue. As a result, the tolerated dose of the drug can be increased, followed by a reduced incidence of neutropenia and cardiotoxicity in comparison to doxorubucin treatment. However, a common adverse dose-schedule limiting effec...

Keratin 9 (K9) is a type I intermediate filament protein whose expression is confined to the suprabasal layers of the palmoplantar epidermis. Although mutations in the K9 gene are known to cause epidermolytic palmoplantar keratoderma, a rare dominant-negative skin disorder, its functional significance is poorly understood. To gain insight into the physical requirement and importance of K9, we g...

Gap junctions, which mediate rapid intercellular communication, consist of connexins, small transmembrane proteins that belong to a large family of proteins found throughout the species. Mutations in the GJB2 gene, encoding Connexin 26, can cause nonsyndromic autosomal recessive or dominant hearing loss with or without skin manifestations. A 3-yr-old Korean female and her mother presented to ou...

338 Early Clinical Differential Diagnosis between Infant Atopic Dermatitis and Seborrheic Eczema Rubens Marcelo Souza Leite, MD, and Adriana Aragao Craveiro Leite, MD. Departamento Medico, Camara dos Deputados, Brasilia, Brazil; Allergy, Instituto Saint Louis, Brasilia, Brazil. Background: Clinical differential diagnosis between atopic dermatitis and seborrheic eczema is sometimes difficult. Ea...

338 Early Clinical Differential Diagnosis between Infant Atopic Dermatitis and Seborrheic Eczema Rubens Marcelo Souza Leite, MD, and Adriana Aragao Craveiro Leite, MD. Departamento Medico, Camara dos Deputados, Brasilia, Brazil; Allergy, Instituto Saint Louis, Brasilia, Brazil. Background: Clinical differential diagnosis between atopic dermatitis and seborrheic eczema is sometimes difficult. Ea...

A 5-year-old caucasian boy, born of non-consanguineous parents, was referred to the dermatology department due palmar hiperlinearity and multiple 2-3 mm hyperkeratotic circular lesions in soles (Fig. 1). The remaining physical examination unremarkable. There a family history palmoplantar hyperkeratosis mother maternal grandfather. To spare child, punch skin biopsy taken from his mother. Patholo...

Circumscribed palmoplantar hypokeratosis (CPH) is a rare acquired dermatosis first described in 2002. It affects mostly the thenar or hypothenar eminences of palm middle-aged elderly women and manifests clinically with sharply limited, annular erythematous plaques depressed surface, rimmed by slightly raised, keratotic border. Microscopically, circumscribed shows sharp decrease horny layer thic...

BACKGROUND Palmoplantar psoriasis is a difficult to treat variant of plaque psoriasis. OBJECTIVE To study the safety and efficacy of infliximab in non-pustular palmoplantar psoriasis. METHODS Patients with non-pustular palmoplantar psoriasis affecting at least 10% of their palms and soles and with a modified palmoplantar psoriasis area and severity index (m-PPPASI) of at least eight were re...

338 Early Clinical Differential Diagnosis between Infant Atopic Dermatitis and Seborrheic Eczema Rubens Marcelo Souza Leite, MD, and Adriana Aragao Craveiro Leite, MD. Departamento Medico, Camara dos Deputados, Brasilia, Brazil; Allergy, Instituto Saint Louis, Brasilia, Brazil. Background: Clinical differential diagnosis between atopic dermatitis and seborrheic eczema is sometimes difficult. Ea...