During secondary palate development, palatal shelves adhere to each other in the midline to form a midline epithelial seam leading to palatal closure. Cell-cell and cell-extracellular matrix adhesions, which are mediated by cell adhesion receptors, E-cadherin and integrins, are implicated in the process of adhesion of the palatal shelves. Src family kinases (SFK) function downstream of both rec...

introdouction: variations in root canal morphology pose a challenge for successful endodontic treatment. the root canal anatomy of the maxillary first molar has been often described as three roots with four canals (two mesiobuccal, one distobuccal, and one palatal). the occurrence of two palatal canals in one palatal root is quite rare. this report represents the case of a maxillary first molar...

BACKGROUND The maxillary swing procedure has been used as an anterolateral approach to expose the nasopharynx, the central skull base, and its vicinity. The reported incidence of postoperative palatal fistula has ranged from 20% to 25%. The oronasal incompetence especially associated with a large fistula has adversely affected normal speech, eating, and swallowing functions. We describe a modif...

Development of the mammalian secondary palate involves multiple steps of highly regulated morphogenetic processes that are frequently disturbed during human development, resulting in the common birth defect of cleft palate. Neither the molecular processes governing normal palatogenesis nor the causes of cleft palate is well understood. In an expression screen to identify new transcription facto...

The mammalian secondary palate arises by outgrowth from the oral side of the paired maxillary processes flanking the primitive oral cavity. Palatal growth depends on reciprocal interactions between the oral ectoderm and the underlying neural-crest-derived mesenchyme. Previous studies have implicated sonic hedgehog (Shh) as an important epithelial signal for regulating palatal growth. However, t...

Cleft palate is among the most common birth defects in humans. Previous studies have shown that Shh signaling plays critical roles in palate development and regulates expression of several members of the forkhead-box (Fox) family transcription factors, including Foxf1 and Foxf2, in the facial primordia. Although cleft palate has been reported in mice deficient in Foxf2, whether Foxf2 plays an i...

Introduction: The purpose of this study was to evaluate vertical facial and dental changes after orthodontic treatment with extraction of first four premolars, and to find whether long facial height could influence the treatment result. Methods: Fifty-six orthodontic patients with the minimum age of 15, whose treatment plan involved extracting four first premolars, participated in the study. Th...

A female patient, 36-years-old, complained of bilateral palatal pain on the anatomical area of upper second molars. The painful condition of palatal mucosa erosion was observed. Palatal erosions or ulcerations may be caused by heated food cooked in microwave ovens. We present a case of a bilateral palatal burn caused by cheese-pie. Concluding, any food containing cheese, when heated in microwav...

The present investigation examines palatal production as well as the relation of phonology and phonetics in Greek. In accordance with one production experiment, the results indicate: (1) palatal productions that surface from one underlying segment are significantly longer than palatal productions that surface from two underlying segments, (2) palatal productions are voice assimilated with the p...