Vitamin D deficiency is an emerging health concern around the world, highly prevalent in south Asian population, despite abundant sunlight. In Pakistan, all age groups are vulnerable to Vitamin D deficiency including pregnant women. This systematic review aimed to determine the pattern of Vitamin D deficiency among Pakistani pregnant women as well as exploring the causes and possible interventi...

.. HbA1c gives an integrated index of glycemia over the entire 120 days life span of red blood cells. Therefore, measuring HbA1c would be appropriate in diagnosing a disease characterized by chronic hyperglycemia and a gradual progression to complications. Objectives: our primary objective was to evaluate the use of HbA1c as screening test for undiagnosed diabetes (WHO criteria of Fasting plasm...

ERCC5 plays crucial role in excision repair DNA damage induced by UV in NER pathway. Single neuleotide polymorphism in ERCC5 were responsible for different cancers.Therefore, current study evaluated the relationship between ERCC5 (rs1047768 T>C) polymorphism and the risk of breast cancer in Pakistani population. The rs1047768 polymorphism was screened among 175 female...

BACKGROUND There is little population-based evidence on ethnic variation in the most common mental disorders (CMD), anxiety and depression. We compared the prevalence of CMD among representative samples of White, Irish, Black Caribbean, Bangladeshi, Indian and Pakistani individuals living in England using a standardized clinical interview. METHOD Cross-sectional survey of 4281 adults aged 16-...

Objective: Aceclofenac is a phenylacetic acid derivative; this nonsteroidal anti-inflammatory drug is a potent anti-inflammatory analgesic and antipyretic. The objectives of this study were to conduct a pharmacokinetic study of aceclofenac in a Pakistani population, to compare the pharmacokinetic profile of the local population with the United Kingdom (UK) and to determine the effect of sucralf...

mental retardation (mr) is one of the most frequently found major genetic disorders around the world, affecting 1-3% of the people in the general population. the recent advancement in molecular biology and cytogenetic study has made possible the identification of new genes for a variety of genetic disorders including autosomal recessive mr. recessive genetic disorders are common in pakistan due...

The occurrence of cystic fibrosis is very rare in the Asian population. Carriers of the mutations most commonly found in Caucasians were not detected in a large Asian population sample of almost 900 chromosomes. However, an affected Pakistani child born to consanguineous parents was further investigated and shown to be homozygous for the mutation S549N (G-->A). Molecular and clinical data are p...

ERCC5 plays crucial role in excision repair DNA damage induced by UV in NER pathway. Single neuleotide polymorphism in ERCC5 were responsible for different cancers.Therefore, current study evaluated the relationship between ERCC5 (rs1047768 T>C) polymorphism and the risk of breast cancer in Pakistani population. The rs1047768 polymorphism was screened among 175 female...