Objective To examine the incidence of nonsynonymous missense variants in SCN9A (NaV1.7), SCN10A (NaV1.8), and SCN11A (NaV1.9) in patients with painful and nonpainful peripheral neuropathy. Methods Next-generation sequencing was performed on 457 patient DNA samples provided by the Peripheral Neuropathy Research Registry (PNRR). The patient diagnosis was as follows: 278 idiopathic peripheral ne...

Diabetic neuropathy is a common problem and can present various clinical presentations such as cranial neuropathy, radiculopathy, plexopathy, mononeuropathy, polyneuropathy and autonomic neuropathy. Clinical evaluation and use of scoring systems for the evaluation of diabetic polyneuropathy is an important step to get correct diagnosis. New informations about the diagnosis of diabetic neuropath...

OBJECTIVE To assess the effect of high-dose vitamin D in patients with painful diabetic neuropathy. METHODS A single intramuscular dose of 600 000 IU vitamin D was administered, and the effects on metabolic parameters and neuropathic pain assessed over 20 weeks. RESULTS 143 participants with predominantly type 2 diabetes, aged 52.31±11.48 years, with a Douleur Neuropathique 4 (DN4) score (3...

Background: Painful diabetic neuropathy has been identified as the major determinant of depressive symptoms in people with diabetes. It is also known that manifestations can be heterogeneous and sometimes insidious to recognize treat. Clinical case: We present diagnostic-therapeutic course a case which was strongly influenced by significant psychopathological component. Discussion/Conclusions: ...

Diabetes and cancer chemotherapies are often associated with painful neuropathy. The mechanisms underlying neuropathic pain remain poorly understood, and the current therapies have limited efficacy and are associated with dose-limiting side effects. We recently described the pharmacological characterization of cholest-4-en-3-one, oxime (TRO19622), a cholesterol-like compound, that significantly...

Neuropathic pain represents a major medical problem and treatment has been unsatisfactory. Therefore, a new concept to classify neuropathic pain was proposed in which pain is analyzed on the basis of underlying mechanisms rather than on the basis of the causing etiology. The German Research Network on Neuropathic Pain established a large data-base of clinical as well as standardized quantitativ...

Diabetic poly neuropathy (DPN) is the most common chronic complication of type 2 diabetes. Aim of this observational cross sectional study is to establish correlation between level of TNF α and severity of DPN if any. The forty seven subjects were divided into three groups. Group1:15 healthy normal controls; Group2:12 T2DM patients without neuropathy controls; Group3:20 T2DM patients with painf...

Diabetes mellitus (DM) is a common chronic medical problem worldwide; one of its complications is painful peripheral neuropathy, which can substantially erode quality of life and increase the cost of management. Despite its clinical importance, the pathogenesis of painful diabetic neuropathy (PDN) is complex and incompletely understood. Voltage-gated sodium channels (VGSCs) link many physiologi...

Background: Pain caused by diabetic neuropathy is a common complication in diabetic patients. Microcurrent therapy is currently being used as an alternative treatment option for painful diabetic neuropathy, yet little research has been done to date on the efficacy of this treatment option in randomized controlled trials as compared to placebo. This systematic review was performed because there ...