نتایج جستجو برای: pain insensitivity
تعداد نتایج: 250603 فیلتر نتایج به سال:
Congenital insensitivity to pain with anhidrosis is a rare autosomal recessive disorder presenting with loss of pain sensation, thermal sensation defects, and self-mutilating behavior. In the present study, we recruited two consanguineous pedigree showing pain insensitivity symptoms from Pakistan for clinical and molecular investigations. In family A, one female patient displayed classical CIPA...
Voltage-gated sodium channel (NaV) mutations cause genetic pain disorders that range from severe paroxysmal pain to a congenital inability to sense pain. Previous studies on NaV1.7 and NaV1.8 established clear relationships between perturbations in channel function and divergent clinical phenotypes. By contrast, studies of NaV1.9 mutations have not revealed a clear relationship of channel dysfu...
Chronic pain is a major global public health issue causing a severe impact on both the quality of life for sufferers and the wider economy. Despite the significant clinical burden, little progress has been made in terms of therapeutic development. A unique approach to identifying new human-validated analgesic drug targets is to study rare families with inherited pain insensitivity. Here we have...
Patients with congenital insensitivity to pain and anhydrosis syndrome are at risk for renal amyloidosis and inflammatory bowel disease. Physicians caring for such patients should be aware of these complications.
Empathy is a complex form of psychological inference that enables us to understand the personal experience of another person through cognitive/evaluative and affective processes. Recent findings suggest that empathy for pain may involve a 'mirror-matching' simulation of the affective and sensory features of others' pain. Despite such evidence for a shared representation of self and other pain a...
Anesthesia is a state of insensitivity the whole body or part to environmental stimuli and pain. Depending on type anesthesia, it may involve some degree change in consciousness. General anesthesia sleep-like condition which patient consciously does not experience any from environment. Regional involves series procedures that prevent transmission painful specific central nervous system associat...
We propose arrays of all-passive remote sensors with freedom from both source phase-induced intensity noise and cross talk between sensors. These arrays employ high-duty-cycle time-domain addressing, utilize laser diodes, and have downlead insensitivity. A synthetic heterodyne demodulation technique is used to prevent environmentally induced signal fading. An experimental all-fiber implementati...
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