AIM To confirm previous conclusions on Saccharomyces cerevisiae (S. cerevisiae) CNCM I-3856 for irritable bowel syndrome (IBS) management. METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal (GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. ...

BACKGROUND Treatment options that improve overall symptoms of irritable bowel syndrome with constipation (IBS-C) are lacking. AIM A prespecified further analysis to evaluate the efficacy and safety of linaclotide, a guanylate cyclase C agonist, in patients with IBS-C, based on efficacy parameters prespecified for European Medicines Agency (EMA) submission. METHODS Two randomised, double-bli...

BACKGROUND Body-powered prostheses require cable operation forces between 33 and 131 N. The accepted upper limit for fatigue-free long-duration operation is 20% of a users' maximum cable operation force. However, no information is available on users' maximum force. OBJECTIVES To quantify users' maximum cable operation force and to relate this to the fatigue-free force range for the use of bod...

Fermentation of dietary fibres by colonic microbes leads to the production of short chain fatty acids (mainly propionate, butyrate and acetate), which are utilized by the colonic mucosa. Previous studies showed positive effects of butyrate on parameters of oxidative stress, inflammation and apoptosis. Recent studies in rats, however, showed that butyrate increased visceral sensitivity. The aim ...

Varicocele is one of the most common correctable causes male infertility. can also cause scrotal pain or discomfort. Treatment varicocele proved to have benefits in terms fertility and pain. There are many treatment options for varicocele. This review aims describe procedures determine outcomes, advantages disadvantages each option.

background: particular circumstances in the intensive care unit have led the patients to experience significant levels of pain and discomfort. on the other hand, these patients cannot express their discomfort due to several reasons. aim: to develop the causes of discomfort in the intensive care units. methods: in order for assessing the causes of discomfort, the initial questionnaire was extrac...

OBJECTIVES To investigate and compare postoperative pain after one-visit root canal treatment (RCT) on teeth with vital pulps using three different obturation techniques. STUDY DESIGN Two hundred and four patients (105 men and 99 women) aged 12 to 77 years were randomly assigned into three treatments groups: cold lateral compaction of gutta-percha (LC), Thermafil technique (TT), and Backfill ...

PURPOSE A systematic review of the literature was conducted to answer the following questions: 1. Does usage or weight of load carriage system cause pain, perceived exertion or discomfort? 2. Can load carriage system placement on the spine influence pain, perceived exertion or discomfort? 3. Can load carriage system design influence the amount of pain, perceived exertion or discomfort caused by...