A nanodrug delivery system of paclitaxel-mesoporous silica nanoparticles with a core-shell structure (PAC-csMSN) was used to increase the dissolution of paclitaxel (PAC) and improve its treatment of lung cancer. PAC was loaded into the core-shell mesoporous silica nanoparticles (csMSN) by the adsorption equilibrium method and was in an amorphous state in terms of its mesoporous structure. In vi...

OBJECTIVE To examine the impact of a national intervention to improve the postabortion care (PAC) content of midwifery education in Nigeria. METHODS A 3-part quantitative assessment was carried out during and post-intervention. The first baseline component developed and examined the intervention to improve teaching capacity and improve the PAC curriculum among 6 midwifery schools that were to...

A study was conducted on the efficacy of the system based on the simultaneous use of ozone and powdered activated carbon (PAC) in removing sodium dodecylbenzenesulphonate (SDBS) from drinking waters and on the influence of operational parameters (PAC dose, ozone dose and presence of radical scavengers [HCO3-]) on this process. Results obtained showed that low doses of PAC during SDBS ozonation ...

Thermal treatment is simple and has high potential in activated carbon (AC) modification because its functional groups, structures, pores can be significantly modified. However, the changes characteristics of ACs, affecting catalytic activity, have not been investigated enough. Therefore, this study, a coal-based powdered AC (PAC) was thermally treated, characterized, subjected to removal an an...

Paclitaxel (Pac) is an antitumor agent that is widely used for treatment of solid cancers. While being effective as a chemotherapeutic agent, Pac in high doses is neurotoxic, specifically targeting sensory innervations. In view of these toxic effects associated with conventional chemotherapy, decreasing the dose of Pac has been recently suggested as an alternative approach, which might limit ne...

BACKGROUND Pancreatic cancer, composed principally of pancreatic adenocarcinoma (PaC), is the fourth leading cause of cancer death in the United States. PaC-associated diabetes may be a marker of early disease. We sought to identify molecules associated with PaC and PaC with diabetes (PaC-DM) using a novel translational bioinformatics approach. We identified fatty acid binding protein-1 (FABP-1...

INTRODUCTION In Ghana, the provision of postabortion care (PAC) by trained midwives is critical to the efficient and cost-effective reduction of unsafe abortion morbidity and mortality. METHODS We performed a secondary analysis of provider data from a representative sample of Ghanaian health facilities in order to consider the determinants of PAC provision among both physicians and midwives. ...

Optimized purification of oligomeric proanthocyanidines (PAC) from cranberry generated PAC-1A which selectively affected the viability of various neuroblastoma (NB) cell lines representing a spectrum of high-risk NB features. PAC-1A caused a loss of mitochondrial transmembrane depolarization potential (∆Ψm) and increased generation of reactive oxy...