Endotoxin producing bacteria cause disseminated intravascular coagulation (DIC); however, the mechanism of endotoxin action in man is still unclear. Impairment of the fibrinolytic system has been suggested as a contributing mechanism. A single injection of Escherichia coli lipopolysaccharide in rabbits resulted in a marked and prolonged increase of the levels of a fast-acting inhibitor of plasm...

Objective: To assess the prevalence and associated factors of patellofemoral pain syndrome (PFPS) in young adult women with low to moderate physical activity levels (PA). Methods: Women with low to moderate PA, aged between 18 and 40 years, were enrolled in this study. A Thai version of the Kujala Patellofemoral Questionnaire (KPQ), history taking, and physical examination were used to screene...

Given a set of positive integers A = {a1, . . . , an}, we study the number pA(t) of nonnegative integer solutions (m1, . . . ,mn) to ∑n j=1mjaj = t. We derive an explicit formula for the polynomial part of pA. Let A = {a1, . . . , an} be a set of positive integers with gcd(a1, . . . , an) = 1. The classical Frobenius problem asks for the largest integer t (the Frobenius number) such that m1a1 +...

In order to assess which part of the tissue-type plasminogen activator (t-PA) molecule should be (genetically) modified to obtain more-slowly-clearing mutants, two-chain t-PA and its isolated heavy and light chains were radiolabelled and injected into rats. The vast majority of t-PA and the heavy chain disappeared from the blood circulation with half-lives of 2.3 and 1.0 min respectively. The c...

The glycosylation of tissue plasminogen activator (t-PA) obtained from the Bowes melanoma cell line was re-examined using methods of serial lectin affinity chromatography coupled with Bio-Gel P-4 gel filtration chromatography and exoglycosidase sequencing. This study clarified an earlier discrepancy in the literature and confirmed that the major complex N-linked glycans on Bowes t-PA that carry...

Regular physical activity (PA) is one of the most effective recommendations to prevent diabetic complications. However, the reported level of PA is low in this group. This study evaluates intervention based on the implementation intention (II) theory, to improve the level of PA and the health of patients with diabetes. Materials and Methods: This randomized control study was conducted on 124 p...

Background: Pectin is composed of complex polysaccharides that can inhibit cancer metastasis and proliferation with no evidence of toxicity. In the present study, the apoptotic and necrotic effects of pectic acid (PA) on the rat pituitary GH3/B6 tumor cells has been investigated. Methods: GH3/B6 cells were cultured in the Ham’s F12 medium enriched with 15% horse serum and 2.5% fetal bovine seru...

AIM To evaluate the nature of accelerated fibrinolysis in hepatosplenic schistosomiasis. METHODS The biological activity of plasminogen (Plg), plasminogen activators (PA), alpha 2-antiplasmin (alpha 2-AP) and plasminogen activator inhibitor-1 (PAI-1) was determined by photometric analysis in 15 compensated and 35 decompensated patients with endemic Egyptian hepatosplenomegaly. Quantitative me...

Detection of antigen-specific CD4+ T cells is facilitated by the use of fluorescently labeled soluble peptide-major histocompatibility complex (MHC) multimers which mirror the antigen specificity of T-cell receptor recognition. We have used soluble peptide-MHC class II tetramers containing peptides from the protective antigen (PA) of Bacillus anthracis to detect circulating T cells in periphera...