Limited proteolysis of the core domain of the 36-kDa protein p36 by trypsin gives a first insight into the structural organization of the four annexin repeats. Trypsin opens only a single peptide bond, situated between residues 204 and 205. The two fragments (of 20 kDa and 15 kDa), each containing two annexin repeats, remain as a tight complex (nicked core), which binds phospholipids in a Ca2(+...

Boyacigiller et al (2006 p81) have stated that ‘A key difference between domestic and global managers is the need for global managers to deal with significantly greater complexity and to be open to the outside world.’ However, Baruch (2002 p36) has made the point that ‘although the concept of globalization reflects true business reality, the idea that there is a certain template-a “gingerbread ...

This paper estimates the impact of first nationwide e-commerce expansion program on rural households. To do so, we combine a randomized control trial with new survey and administrative microdata. In contrast to existing case studies, find little evidence for income gains producers workers. Instead, are driven by reduction in cost living minority households that tend be younger, richer, more rem...

P36. Quantifying the Development of Breast Cancer Surgery-Associated Lymphedema in High-risk Patients Undergoing Axillary Lymph Node Surgery in Consecutive Patients The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. Citation Chattha, Anmol, Parisa Kamali, Charlotte L. Van Veldhuisen, Renata Flecha-Hirsch, Alexandra Buckno...

Voluntary wheel running of mice in pregnancy and lactation led to a twofold increase in hippocampal precursor-cell proliferation and in the number of Prox1-expressing lineage-determined cells at postnatal day 8 (P8). At P36, the number of newly generated granule cells approximately doubled, resulting in a 40% higher total number of granule cells in pups from running dams as compared with contro...