The preparation of synthetic ribonucleic acid in which one of the nucleotide species is labeled with P32, makes possible studies on the distribution of the labeled nucleotide in the polynucleotide chain. Fig. 1 presents the structure of a polynucleotide in which labeled adenylic acid is randomly distributed. Hydrolysis of such a polymer with snake venom phosphodiesterase (Fig. 1A) will yield a ...

Let k≥1 be an integer. We prove that a suitable asymptotic formula for the average number of representations integers n=p1k+p22+p32, where p1, p2, p3 are prime numbers, holds in intervals shorter than ones previously known.

dria to provide a stable intracellular niche for replication (Luhrmann and Roy, 2007). The pathogen also activates Akt and Erk1/2 signaling to promote survival (Voth and Heinzen, 2009). Each of these events relies on Coxiella protein synthesis, suggesting the organism secretes a distinct effector(s) to regulate apoptosis. Unfortunately, effector identification and characterization has been hamp...

We recently reported that NHE3 exists in multimeric complexes with dipeptidyl peptidase IV (DPPIV) in renal brush-border membranes. To examine the possible role of DPPIV in modulating NHE3 activity, we evaluated whether specific competitive inhibitors that bind to the active site of DPPIV affect NHE3 activity in the OKP line of opossum kidney proximal tubule cells. The DPPIV inhibitors diprotin...

C/EBPe is essential for granulocytic differentiation. We investigated the role of C/EBPe in the transcriptional activation of various myeloid-specific genes. We found that two C/EBPe isoforms, p32 and p30, possessing transcriptional activation domains were coexpressed in myeloid cells. Interestingly, isoform C/EBPe p30 but not p32 was differentially upregulated in NB-4 promyelocytic leukemia ce...

Agrin, a component of the synaptic basal lamina, has been shown to induce clustering of ACh receptors on the surface of muscle fibers. Analysis of cDNAs isolated from a rat embryonic spinal cord library demonstrated that agrin contains domains similar to regions of protease inhibitors, laminin and epidermal growth factor. The domain structure of agrin is further revealed here in an analysis of ...