We report the generation of a macroscopic singlet state in a cold atomic sample via quantum nondemolition measurement-induced spin squeezing. We observe 3 dB of spin squeezing and detect entanglement with 5σ statistical significance using a generalized spin-squeezing inequality. The degree of squeezing implies at least 50% of the atoms have formed singlets.

Objectives Dichotomizing continuous data prior to analysis is rarely a good idea as power is lost. However expressing results as a difference of means is not always meaningful for clinicians; small differences in means may seem clinically unimportant while the same study results expressed as a difference/ratio of proportions or number needed to treat might reveal an effect that is considered wo...

In comparing multiple treatments, 2 error rates that have been studied extensively are the familywise and false discovery rates. Different methods are used to control each of these rates. Yet, it is rare to find studies that compare the same methods on both of these rates, and also on the per-family error rate, the expected number of false rejections. Although the per-family error rate and the ...

Assessing genome-wide statistical significance is an important issue in genetic studies. We describe a new resampling approach for determining the appropriate thresholds for statistical significance. Our simulation results demonstrate that the proposed approach accurately controls the genome-wide type I error rate even under the large p small n situations.

Hi-C is one of the main methods for investigating spatial co-localisation of DNA in the nucleus. However, the raw sequencing data obtained from Hi-C experiments suffer from large biases and spurious contacts, making it difficult to identify true interactions. Existing methods use complex models to account for biases and do not provide a significance threshold for detecting interactions. Here we...

In our recent systematic review in Obstetrics and Gynecology International of the association between FGM/C and obstetric harm we concluded that FGM/C significantly increases the risk of delivery complications. The findings were based on unadjusted effect estimates from both prospective and retrospective studies. To accommodate requests by critics, we aimed to validate these results through add...