BACKGROUND Rabies virus (RABV) causes rabies disease resulting in >55,000 human deaths/year. The multifunctional RABV P-protein has essential roles in genome replication, and forms interactions with cellular STAT proteins that are thought to underlie viral antagonism of interferon-dependent immunity. However, the molecular details of P-protein-STAT interaction, and its importance to disease are...

Intraperitoneal injection of epidermal growth factor into mice results in the appearance of multiple tyrosine-phosphorylated proteins in liver nuclei within minutes after administration. We have previously identified three of these proteins as Stat 1 alpha, Stat 1 beta (p91, p84), and Stat 3 (p89). In the present report we demonstrate that Stat 5 (p92), the recently described prolactin inducibl...

INTRODUCTION Recent advances in the diagnosis and treatment of influenza virus infections include: (1) rapid bedside diagnosis methods with simple commercially available tests; and (2) Food and Drug Administration approval of treatment for children 1 year of age and older with neuraminidase inhibitor drugs. For proven benefit antivirals should be used within 2 days of onset of symptoms. OBJEC...

OBJECTIVE Intercellular adhesion molecule-1 (ICAM-1) is upregulated rapidly on endothelial cells during ischemia-reperfusion (I-R) and mediates tissue leukocyte accumulation. The ICAM-1 proximal promoter contains a signal transducer and activator of transcription (Stat) binding motif (gamma-interferon activation site [GAS] sequence), which flanks a specificity protein 1 (Sp1) binding site. We e...

Large-scale sparse precision matrix estimation has attracted wide interest from the statistics community. The convex partial correlation selection method (CONCORD) developed by Khare et al. (J R Stat Soc Ser B (Stat Methodol) 77(4):803–825, 2015) recently been credited with some theoretical properties for estimating matrices. CONCORD obtains its solution a coordinate descent algorithm (CONCORD-...

Nous analysons les modéles d’Ising/Curie–Weiss sur le graphe Erdős–Rényi avec N sommets et probabilité d’arête p=p(N) introduits par Bovier Gayrard (J. Stat. Phys. 72 (3–4) (1993) 643–664) étudié dans 177 (1) (2019) 78–94) (Kabluchko, Löwe and Schubert (2019)). montrons des théorèmes limite central pour la fonction de partition du modèle – à autres régimes p(N) logarithmique. trouvons critiques...

the aim of this study was to develop and obtain the reliability and validity of 8 items short form of spielberger stat-trait anxiety inventory (stai) for use in circumstances where the full form is inappropriate. in this study a correlational method is carried out. using the available sampling, the sample subjects were selected from 161 patients who referred to one of hospitals of isfahan. in t...

We report measurements of the branching fractions singly Cabibbo-suppressed decays $\Lambda_c^+ \to p \eta$ and \pi^0$ using full Belle data sample corresponding to an integrated luminosity 980.6 $\rm fb^{-1}$. The were collected by detector at KEKB $e^{+}$$e^{-}$ asymmetric-energy collider. A clear $\Lambda_c^+$ signal is seen in invariant mass distribution $p \eta$. yield process $7734 \pm 26...

UNLABELLED Jugular venous oxygen saturation (SJVO(2)) reflects the balance between cerebral blood flow and metabolism. This study was designed to compare the effects of two different acid-base strategies on jugular venous desaturation (SJVO(2) <50%) and cerebral arteriovenous oxygen-glucose use. We performed a prospective, randomized study in 52 patients undergoing cardiopulmonary bypass (CPB) ...

We previously reported that infection by Mycobacterium tuberculosis, the causative agent of tuberculosis, leads to secretion of alpha/beta interferon (IFN-alpha/beta). While IFN-alpha/beta ordinarily stimulates formation of signal transducer and stimulator of transcription-1 (STAT-1) homodimers and IFN-stimulated gene factor-3 (ISGF-3), only ISGF-3 is found in infected human monocytes and macro...