BACKGROUND Our objective was to compare 111In- or 64Cu-DOTA-trastuzumab Fab fragments for imaging small or large s.c. tumor xenografts in athymic mice that display a wide range of human epidermal growth factor receptor-2 (HER2) expression using microSPECT/CT or microPET/CT. METHODS Trastuzumab Fab were labeled with 111In or 64Cu by conjugation to 1,4,7,10-tetraazacyclododecane N, N', N'', N''...

BACKGROUND We previously described a two-antibody model of (64)Cu radioimmunotherapy to evaluate low-dose, solid-tumor response. This model was designed to test the hypothesis that cellular internalization is critical in causing tumor cell death by mechanisms in addition to radiation damage. The purpose of the present study was to estimate radiation dosimetry for both antibodies (mAbs) using po...

C-aryl derivatives of DOTA (N,N’,N”,N”’-tetrakis(carboxymethyl)1,4,7,10-tetraazacyclododecane) including phenyl-DOTA and 3-NO2Ph-DOTA were synthesized by a template reductive reaction. GaCl3 or GaCl3 was taken and transformed into Ga-acetylacetone (Ga(acac)3) before labeling to the DOTA derivatives. The Ga or Ga labeled complexes were generated by ligand-ligand exchange of acetylacetonate with ...

Individual neurons within the suprachiasmatic nuclei (SCNs) are capable of functioning as autonomous clocks and generating circadian rhythms in the expression of genes that form the molecular clockworks. Limited information is available on how these molecular oscillations in individual clock cells are coordinated to provide for the ensemble rhythmicity that is normally observed from the entire ...

Introduction: Although several studies have explored iron indices in patients with sickle cell anaemia (SCA), there is a paucity of evidence regarding the status nephropathy (SCN). This study evaluated range adult SCA or without Lagos, Nigeria.Methods: was cross-sectional performed at Sickle Cell Clinic Lagos University TeachingHospital (LUTH). Patients who were aged 18–65 years assessed for SC...

BACKGROUND High-grade gliomas (HGGs) express somatostatin receptors (SSTR), rendering them candidates for peptide receptor radionuclide therapy (PRRT). Our purpose was to evaluate the potential of (68)Ga-DOTA-1-Nal(3)-octreotide ((68)Ga-DOTANOC) or (68)Ga-DOTA-Tyr(3)-octreotide ((68)Ga-DOTATOC) to target SSTR subtype 2 (SSTR2) in HGGs, and to study the association between SSTR2 expression and e...

BACKGROUND 44Sc as a positron emitter can be an interesting alternative to 68Ga (T½=67.71 min) due to its longer half-life (T½=3.97 h). Moreover, the b-emitter 47Sc can be used for therapy when attached to the same biomolecule vectors. DOTA as a chelating agent has been proven suitable for the radiolabelling of peptides recognising tumour cell receptors in vivo with M3+ radiometals. DOTA-deriva...

Individual neurons within the suprachiasmatic nuclei (SCNs) are capable of functioning as autonomous clocks and generating circadian rhythms in the expression of genes that form the molecular clockworks. Limited information is available on how these molecular oscillations in individual clock cells are coordinated to provide for the ensemble rhythmicity that is normally observed from the entire ...

The present study aimed to develop a monoclonal antibody (mAb)-based double functional probe for PET and near-infrared fluorescence (NIRF) targeting CD20 and to cross validate the targeting efficacy of this dual functional probe. NuB2, anti CD20 mAb was conjugated with Alexa Fluor 750 and 64Cu through DOTA chelator. PET and NIRF imaging was carried out at 30 min and 24 h post-injection with 64C...

Chung, Diaconis, and Graham considered random processes of the form Xn+1 = 2Xn + bn (mod p) where X0 = 0, p is odd, and bn for n = 0, 1, 2, . . . are i.i.d. random variables on {−1, 0, 1}. If Pr(bn = −1) = Pr(bn = 1) = β and Pr(bn = 0) = 1 − 2β, they asked which value of β makes Xn get close to uniformly distributed on the integers mod p the slowest. In this paper, we extend the results of Chun...