BACKGROUND & AIMS We previously used a novel biomedical optics technology, 4-dimensional elastically scattered light fingerprinting, to show that in experimental colon carcinogenesis the predysplastic epithelial microvascular blood content is increased markedly. To assess the potential clinical translatability of this putative field effect marker, we characterized the early increase in blood su...

Near-infrared spectroscopy is a novel and promising technology for cost effective and noninvasive brain imaging in research and clinical practice. Utilizing the fact that near-infrared light is mostly absorbed by tissue hemoglobin, one can measure the intensity of light scattered and reflected by tissue (e.g., brain) to track local changes in hemoglobin concentrations within cortical layers (ne...

studies have shown that oxygenated compounds and tss/ta are important for beverage and food industries. it seems that citrus rootstocks have a profound influence on oxygenated compounds and tss/ta. the aim of this research is to identify rootstock that can synthesize the maximum level of oxygenated compounds and tss/ta. peel oil was extracted using mechanical presses and eluted using n-hexane. ...

objectives in this study, the absorption coefficient of hemoglobin (hb) was used to distinguish between normal and abnormal breast tissue. materials and methods a near-infrared source (637 nm) was transmitted from major and minor vessels of a breast phantom containing 2×, 4× concentrations of oxy- and deoxy-hb. the absorption coefficients were determined from spectrometer (sm) and powermeter (p...

Because the refractive index of hemoglobin in the visible range is sensitive to the hemoglobin concentration, optical investigations of hemoglobin are important for medical diagnostics and treatment. Direct measurements of the refractive index are, however, challenging; few such measurements have previously been reported, especially in a wide wavelength range. We directly measured the refractiv...

The biological roles of nitric oxide (NO)-hemoglobin (Hb) derivatives are obscure. It is proposed that NO can function as an allosteric regulator of hemoglobin oxygen-binding properties. We aimed to estimate the effects of NO donors and NO-synthase substrate (L-arginine) on hemoglobin-oxygen affinity (HOA) in experiments in vitro with the various ratios between NO formed and Hb and various oxyg...

The sulfhydryl titration of hemoglobin Rainier (wl32 146Tyr-‘Cys) suggests that the cysteine residue HC2(145)/3 forms a disulfide bridge with the cysteine F9(93)/3 of the same /3 chain. The oxygen equilibrium of Hb-Rainier compared with that of HbA exhibits diminished heme-heme interaction (n = 1.3-1.5), increased oxygen affinity, and a small Bohr effect. The absorption spectrum and the circula...

For adults and children, genetic and environmental factors are known to affect brain structure and neural activity necessary for conducting various cognitive tasks. However, little is known regarding genetic and environmental contributions to individual differences in neural activity during the first two years of life. Concentrations of oxygenated and deoxygenated hemoglobin were measured bilat...

An accurate SO(2) prediction method for using broadband continuous-wave diffuse reflectance near infrared (NIR) spectroscopy is proposed. The method fitted the NIR spectra to a Taylor expansion attenuation model, and used the simulated annealing method to initialize the nonlinear least squares fit. This paper investigated the effect of potential spectral interferences that are likely to be enco...