Antioxidants are compounds that protect cells against reactive oxygen cells – or free radicals -in the body. Although they are created as part of the body’s normal metabolic functions, free radicals react with other cells and may interfere with their ability to function. Free radicals are believed to play a role in many health conditions, ranging from cancer and atherosclerosis to wrinkles caus...

Free radicals and oxidative stress play important roles in the deterioration of materials, and free radicals are important intermediates in many biological processes. The ability to detect these reactive species is a key step on the road to their understanding and ultimate control. This short review highlights recent progress in the development of reagents for the detection of free radicals and...

Oxygen-derived free radicals are normally generated in many pathways. These radicals can interact with various cellular components and induce cell injury. When free radicals exceed the antioxidant capacity, cell injury causes diverse pathologic changes in the organs. The imbalance between the generation of free radicals and antioxidant defence is known as oxidative stress. The eye can suffer th...

Free radicals are common outcome of normal aerobic cellular metabolism. In-built antioxidant system of body plays its decisive role in prevention of any loss due to free radicals. However, imbalanced defense mechanism of antioxidants, overproduction or incorporation of free radicals from environment to living system leads to serious penalty leading to neuro-degeneration. Neural cells suffer fun...

Apoptosis has been hypothesized to be mediated through the induction of free radicals via oxidative pathways. Furthermore, it has been proposed that Bcl-2 acts to inhibit apoptosis induced by a wide variety of stimuli by preventing the production of oxygen-derived free radicals. Since the generation of oxygen free radicals is dependent upon oxygen concentration, this hypothesis would lead to th...

1 Oxygen Free Radicals in Tissue Injury. Ciba Foundation symposium. Amsterdam: Excepta-Medica, 1979 2 Fantone JC, Ward PA. The role of oxygen derived free radicals and metabolites in leukocyte dependent inflammatory reactions. Am J Pathol 1982; 107. 3 Johnson KJ, Ward PA. Role of oxygen metabolites in immune complex injury of lung. J Immunol 1981; 126:2365-69 4 Johnson KJ, Ward PA. Lung injury ...

When someone is inactive the energy and oxygen accumulate to dangerous levels instead of being burned off. This creates an excess of free radicals. If one is consuming too many calories this adds more energy to the mitochondrion and contributes to the free radicals. Anti-oxidants generated within the mitochondrion can neutralise the free radicals and help prevent damage. Physical activity helps...

Free radicals derived from molecular oxygen and nitrogen are highly reactive metabolites called reactive oxygen species (ROS). Cells continuously produce free radicals and ROS as part of the metabolic process. They are involved in the various functions of the reproductive system. Antioxidants are enzymes or compounds that scavenge and reduce the presence of free radicals. Normally, a balance ex...

The concentrations of ROS were measured in samples of the sensorimotor brain cortex and in the rat blood. We measured the following parameters: The six lines spectra, nitroxide radical, free hydroxyl radical and singleton oxygen. Their concentration was measured under physiological conditions, after the nociceptive stimulation and after the application of melatonin, both in normal and stimulate...