Indirubin, a red colored 3,2'-bisindole isomer, is a component of Indigo naturalis and is an active ingredient used in traditional Chinese medicine for the treatment of chronic diseases. The family of indirubin derivatives, such as indirubin-3'-oxime, has been suggested for various therapeutic indications. However, potential toxic interactions such as indirubin effects on mitochondrial bioenerg...

Aerobic reactions of Co(O(2)CMe)(2).4H(2)O with di-2-pyridyl ketone oxime (Hpko) in the presence of counterions (ClO(4)(-), PF(6-)) give the tetranuclear, mixed-valence cobalt(II/III) clusters [Co(II)(2)Co(III)(2)(OR)(2)(O(2)CMe)(2)(pko)(4)S(2)]X(2) [R = H, S = MeOH, X = ClO(4) (1); R = Me, S = EtOH, X = PF(6) (2)] depending on the solvent mixture. Complexes 1 and 2 are the first Co members in ...

Buchwald-Hartwig-Migita cross-coupling of 1-thiosugars with α- or β-3-iodo-N-glycosylquinolin-2-ones has been accomplished under mild and operationally simple reaction conditions through the use of a Pd-G3 XantPhos palladacycle precatalyst. This new methodology has been successfully applied to a variety of α- or β-mono-, di-, and poly-thiosugar derivatives to efficiently synthesize a series of ...

1. Reactivation of erythrocyte cholinesterase inhibited by ethyl p-nitrophenyl ethylphosphonate (armine) was studied with NN'-dimethylenebis-(4-hydroxy-iminomethylpyridinium bromide) (C(2)-oxime), NN'-trimethylenebis-(4-hydroxy-iminomethylpyridinium bromide) (C(3)-oxime), NN'-tetramethylene-(4-hydroxy-iminomethylpyridinium bromide) (C(4)-oxime) and NN'-pentamethylenebis-(4-hydroxyiminomethylpyr...

Reaction of gold trihalides with reducing agents such as thiols, NaBH4 or hydroxylamine gives gold nanoparticles (Au NPs). In particular, NH2OH is used to produce monodisperse colloidal Au NPs by “growing” of smaller particles or to form thin films of Au on glass substrates. Our interest in developing a mild catalytic method for the conversion of nitro/oxime/nitrone groups to carbonyl groups le...

As part of ongoing efforts to design improved nerve agent antidotes, two X-ray crystal structures of Torpedo californica acetylcholinesterase (TcAChE) bound to the bis-pyridinium oxime, Ortho-7, or its experimental bis-imidazolium analogue, 2BIM-7, were determined. Bis-oximes contain two oxime groups connected by a hydrophobic linker. One oxime group of Ortho-7 binds at the entrance to the acti...

The reactions of methyl(2-pyridyl)ketone oxime, (py)C(Me)NOH, with manganese(II) sulfate monohydrate have been investigated. The reaction between equimolar quantities of MnSO(4) . H(2)O and (py)C(Me)NOH in H(2)O lead to the dinuclear complex [Mn(2)(SO(4))(2){(py)C(Me)NOH}(4)] . (py)C(Me)NOH, 1 . (py)C(Me)NOH, while employment of NaOMe as base affords the compound [Mn(HCO(2))(2){(py)C(Me)NOH}(2)...

Zinc(II) complexes with dangling functional organic groups were synthesized by reaction of zinc acetate with a series of bifunctional p-substituted benzene derivatives (a combination of carboxylate, oximate, amino, β-ketoimine, and salicylaldime groups). Selective coordination to carboxylate groups was observed when the second functional group was an oxime or β-ketoimine group. When the second ...

Despite the long term interest in hydroxyoximes as metal ion extractants, there is a lack of information on the possible coordination modes these ligands can assume, particularly in concert with a co-ligand. This is pertinent to the use of these extractants in synergistic systems, where a combination of extractants can achieve commercially useful results. We report here the structures of some m...

The dimeric complex [Mn(III)(2)(Naphth-sao)(2)(Naphth-saoH)(2)(MeOH)(2)]·4MeOH (1·4MeOH), acts as a simple model complex with which to examine the magneto-structural relationship in polymetallic, oxime-bridged Mn(III) complexes. Dc magnetic susceptibility studies reveal that ferromagnetic exchange is mediated through the heavily twisted Mn-O-N-Mn moiety (J = +1.24 cm(-1)) with magnetisation mea...