Ovarian folliculogenesis in mammals from the constitution of primordial follicles up to ovulation is a reasonably well understood mechanism. Nevertheless, underlying mechanisms that determine the number of ovulating follicles were enigmatic until the identification of the fecundity genes affecting ovulation rate in sheep, bone morphogenetic protein-15 (BMP-15), growth and differentiation factor...

The litter size of homozygous Booroola Merino ewes results in high perinatal mortality. One subcutaneous implant of crystaline oestradiol in silastic tubing in heterozygous Booroola Merino ewes decreased ovulation rate from 3.18 -r0.15 (n = 39) to 2.03 & 0.14 (n = 35), and decreased litter size (5 8 weeks pregnant) from 2.49 + 0.13 (n = 39) to 1.47 + 0.12 (n = 32), providing a useful management...

OBJECTIVE To evaluate the impact of intrauterine insemination timing performed 24 or 36 h later following ovulation trigger on clinical pregnancy rate during ovulation induction with clomiphene citrate among infertile women was the objective of this study. METHODS The medical records of 280 infertile patients who have underwent ovulation induction by using clomiphene citrate have been evaluat...

OBJECTIVE To evaluate the effects of berberine on the menstrual pattern, ovulation rate, hormonal and metabolic profiles in anovulatory Chinese women with polycystic ovary syndrome. METHODS Berberine 0.4 g three times per day was given for four months to 102 anovulatory Chinese women with polycystic ovary syndrome. The menstrual pattern, ovulation rate, hormonal and metabolic profiles were co...

MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that play critical roles in animal development and physiology, though functions for most miRNAs remain unknown. Worms with reduced miRNA biogenesis due to loss of Drosha or Pasha/DGCR8 activity are sterile and fail to ovulate, indicating that miRNAs are required for the process of oocyte maturation and ovulation. Starting...

Metformin alone compared with placebo increases the ovulation rate in women with polycystic ovary syndrome (PCOS) but should not be used as first-line therapy for anovulation because oral ovulation induction agents such as clomiphene citrate or letrozole alone are much more effective in increasing ovulation, pregnancy, and live-birth rates in women with PCOS. There is fair evidence that metform...

background polycystic ovary syndrome (pcos) is a common disease in young women that is associated with infertility and other complications such as obesity, hirsutism and insulin resistance and also the disorder that mostly is specified with oligomenorrhoea or amenorrhea with clinical or laboratory evidence of hyperandrogenemia. objectives the purpose of this study was to investigate whether mea...