background: leishmaniasis is a parasitic disease caused by different species of leishmania parasites with a wide range of clinical manifestations . antimonial compounds such as meglumine antimoniate (glucantime) are the first line drugs for the treatment of leishmaniasis. however, according to reports of the drug resistance of parasites, the efficacy of antimonial compounds is low. the atp-bind...

background and objective: egfr and her-2 are two members of erbb/her family of type i transmembrane growth factor receptors. cox2 is an enzyme responsible for the conversion of arachidonic acid to prostaglandins, which has a major role in angiogenesis and can modelate tumor growth. the aim of this study was to determine the level of expression of egfr, her-2 and cox2 in colorectd cancer. mater...

objective(s):eukaryotic translation initiation factor 4e (eif4e) is overexpressed in cervical cancer (cc). however, the molecular mechanisms are unclear. this study aimed to investigate the molecular mechanism of eif4e gene overexpression in cc. materials andmethods:the human papillomavirus (hpv) type 18 e7 and eif4e mrnas were measured following knock down or overexpression of e7 gene by rt-pc...

objective(s): to explore the correlation between expression patterns and functions of mir-383 and ldha in hepatocellular cancer (hcc). materials and methods: we detected the expression of mir-383 and ldha in 30 hcc tissues and their matched adjacent normal tissues using qrt-pcr. then we performed mtt assay, foci formation assay, transwell migration assay, glucose uptake assay and lactate produc...

Abstract Background and Aims Pyroptosis as a necrosis type related to inflammation, is involved in various diseases, including acute kidney injury (AKI). Here, we report that Chromodomain Y-like (CDYL) critical for pyroptosis regulation AKI. Method Cisplatin-induced mouse model cisplatin-induced TCMK-1 cell of AKI were established, serum creatinine (Cr) blood urea nitrogen (BUN) measured evalua...

The living cell possesses extraordinary molecular and biochemical mechanisms by which to recognize efficiently remove foreign, damaged, or denatured proteins. This essential function has been a barrier the overexpression of recombinant proteins in most expression systems. A notable exception is E. coli proteins, which, however, end-up as inclusion bodies, i.e., cytoplasmic aggregates that are i...

The G protein-coupled receptor, class C, group 5, member A (GPRC5A) plays a key role in various diseases, but its effect on hepatocellular carcinoma (HCC) and the potential underlying mechanisms remains unclear. In present study, we explored of GPRC5A progression HCC further mechanism action. results revealed that expression was lower tissues cells. Overexpression suppressed proliferation epith...

Introduction. The occurrence of aortic dissection is related to the proliferation and metastasis vascular smooth muscle cells. In our present study, we found that expression miR-140-5p was inhibited in wall abdominal aorta patients. However, mechanism development unclear. Material methods. We detected NCK Associated Protein 1 (NCKAP1) blood vessel patients normal people by PCR. Next, establishe...

Abstract Background and Aims The peroxisome proliferator-activated receptor-γ (PPARγ) agonists have been shown to dampen TGF-β signaling suppress miR-130a in VSMCs also profibrotic miR-21-5p the kidney. We recently demonstrated that pioglitazone ameliorates established renal fibrosis by suppressing STAT3 EGR1 [1], but its effect on has not investigated. Thus, we aimed study how chronic oral tre...