BACKGROUND Ovarian tissue cryopreservation followed by transplantation after cancer remission is the most commonly applied fertility restoration approach in very young girls and women who require immediate cancer therapy. However, clinicians strongly advise against reimplantation of one's own ovarian tissue when there is a high risk of recurrence after grafting. For these patients, development ...

Spotted scat ( Scatophagus argus ) is an important mariculture fish that of great economic significance in East and Southeast Asia. To date, there are no studies on ovary development regulation S. . Herein, the transcriptome profiles at different stages were constructed, genes pathways potentially involved secondary follicle growth identified. A total 25,426 detected by sequencing mRNAs from li...

background: azadirachta indica is a tree with most of the parts having various medicinal values. it is however popular because of its high potencies, as antimalarial and anti-fertility agents, which the locals still exploit. objective: we investigated the effect of the methanol leaf extract on the serum levels of the pituitary-gonad hormones and the histo-morphology of the ovary and uterus of a...

Anti-müllerian hormone (AmH) or müllerian inhibiting substance (mIS), is a dimeric protein part of the transforming growth factor (TGF)-beta subfamily. It plays two important roles in follicle genesis. First, it delays entrance of primordial follicle into pool of follicles in growth and secondly, it decreases the sensitivity of ovarian follicle toward follicle-stimulating hormone (FSH). The ova...

Polycystic Ovary Syndrome (PCOS) is a female endocrine disorder which severely distresses women’s health. The disorder is characterized by a collection of incomplete developed follicles in the ovaries. Manual analysis of PCOS diagnosis often produces errors. So, in recent years many researchers have been enthusiastically working in automatic detection of PCOS. This paper reviews follicle detect...

OBJECTIVE To develop an in vitro strategy to support the growth of early-stage follicles and produce mature oocytes competent for fertilization. DESIGN Whole ovaries from 8-day-old mice were cultured for 4 days, and then secondary follicles were isolated and cultured for 12 days in a three-dimensional alginate or fibrin-alginate (FA) hydrogel matrix. SETTING University-affiliated laboratory...

In the mammalian ovary, progressive activation of primordial follicles from the dormant pool serves as the source of fertilizable ova. Menopause, or the end of female reproductive life, occurs when the primordial follicle pool is exhausted. However, the molecular mechanisms underlying follicle activation are poorly understood. We provide genetic evidence that in mice lacking PTEN (phosphatase a...

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide originally purified from ovine hypothalamus for its potent activity to stimulate cAMP production. However, its presence and action have also been demonstrated in various peripheral tissues including the ovary. In the zebrafish, two forms of PACAP (PACAP(38)-1, adcyap1a; and PACAP(38)-2, adcyap1b) and three PACAP recept...