In vitro cytotoxic potential of extracts (95% and 50% ethanolic extract and hot water extract at concentration of 100 microg/ml) from leaves of Holarrhena antidysenterica was evaluated against fourteen human cancer cell lines--A-549, COLO-205, DU-145, HeLa, HEP-2, IMR-32, KB, MCF-7, NCI-H23, OVCAR-5, SiHa, SK-N-MC, SW-620 and ZR-75-1 from nine different tissues (breast, colon, cervix, CNS, lung...

PROBLEM There is a lack of validated marker(s) for the diagnosis of early-stage ovarian cancer (OVCA). The objective was to determine if women with OVCA had antibodies, to assess their potential as markers of ovarian cancer. The secondary objective was to compare the prevalence of antibodies to proteins from normal ovary and ovarian tumors to determine if antibodies primarily recognize tumor an...

Transvaginal colour and pulsed Doppler ultrasonography analyses of blood flow velocity have indicated that intra-tumoral peak systolic velocity (PSV) is a good indicator of ovarian malignancy. Therefore, we examined whether there was an association between the expression of angiogenic genes, e.g. thymidine phosphorylase (TP) and TIE2 and the PSV of blood flow in normal and cancerous ovaries. In...

1 Rustin GJS. Tumour markers in germ cell tumours. BrMedJ 1986;292:7134. 2 Lucraft HH. A review of thirty-three cases of ovarian dysgerminoma emphasising the role of radiotherapy. Clin Radiol 1979;30:585-9. 3 Gordon A, Lipton D, Woodruff JD. Dysgerminoma: a review of 158 cases from the Emil Novak Ovarian Tumor Regstry. Obstet Gynecol 1981;58:497-504. 4 Slayton RE, Park RC, Silverberg SG, Shingl...

Cancer treatments can often adversely affect the quality of life young women. One most relevant negative impacts is loss fertility. Cyclophosphamide one detrimental chemotherapeutic drugs for ovary. may induce destruction dormant follicles while promoting follicle activation and growth. Herein, we demonstrate in vivo protective effect allosteric Bcr-Abl tyrosine kinase inhibitor Asciminib on si...

Autoamputated ovary with mature cystic teratoma (MCT) is a rarely reported gynecologic entity with an unknown prevalence. A 34-year-old woman referred to our clinic for presumed left ovarian tumor. Pelvic examination, ultrasonography and computed tomography scan revealed a 5-cm, cystic ovarian mass with calcification and fat component, and tumor markers were as follows, cancer antigen (CA) 125;...

BACKGROUND Natural products represent an important source for agents of cancer prevention and cancer treatment. More than 60% of conventional anticancer drugs are derived from natural sources, particularly from plant-derived materials. In this study, 2α, 3α, 19β, 23β-tetrahydroxyurs-12-en-28-oic acid (THA), a novel triterpenoid from the leaves of Sinojackia sarcocarpa, was isolated, and its ant...

Objectives This is a protocol for Cochrane Review (diagnostic). The objectives are as follows: To assess the diagnostic accuracy of potential screening tests detection atypical hyperplasia (pre‐cancer) and endometrial cancer all stages grades in asymptomatic (healthy) women general population. Secondary determine optimal thickness cut‐off value using transvaginal ultrasound scan hyperplasia. in...

Pain in relation to the menstrual cycle is representative of Endometriosis. It has been reported that Endometriosis can be easily confounded with neoplasia. In clinical practice Gynecologic Oncology we find relative frequency patients who are unknown carriers endometriosis present and operated on because they resemble a picture gynecological cancer, predominantly ovary. Endometriomas form part ...