نتایج جستجو برای: ovarian stem cells

تعداد نتایج: 1568347  

2011
Ayesha B. Alvero Michele K. Montagna Jennie C. Holmberg Vinicius Craveiro David Brown Gil Mor

Cancer stem cells are responsible for tumor initiation and chemoresistance. In ovarian cancer, the CD44þ/ MyD88þ ovarian cancer stem cells are also able to repair the tumor and serve as tumor vascular progenitors. Targeting these cells is therefore necessary to improve treatment outcome and patient survival. The previous demonstration that the ovarian cancer stem cells are resistant to apoptoti...

2011
Ayesha B. Alvero Michele K. Montagna Jennie C. Holmberg Vinicius Craveiro David Brown Gil Mor

Cancer stem cells are responsible for tumor initiation and chemoresistance. In ovarian cancer, the CD44þ/ MyD88þ ovarian cancer stem cells are also able to repair the tumor and serve as tumor vascular progenitors. Targeting these cells is therefore necessary to improve treatment outcome and patient survival. The previous demonstration that the ovarian cancer stem cells are resistant to apoptoti...

Journal: :International journal of cancer 2012
Ilona Kryczek Suling Liu Michael Roh Linhua Vatan Wojciech Szeliga Shuang Wei Mousumi Banerjee Yujun Mao Jan Kotarski Max S Wicha Rebecca Liu Weiping Zou

Identification of cancer stem cells is crucial for advancing cancer biology and therapy. Several markers including CD24, CD44, CD117, CD133, the G subfamily of ATP-binding cassette transporters (ABCG), epithelial specific antigen (ESA) and aldehyde dehydrogenase (ALDH) are used to identify and investigate human epithelial cancer stem cells in the literature. We have now systemically analyzed an...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
Xiaolong Wei David Dombkowski Katia Meirelles Rafael Pieretti-Vanmarcke Paul P Szotek Henry L Chang Frederic I Preffer Peter R Mueller Jose Teixeira David T MacLaughlin Patricia K Donahoe

Cancer stem cells are proposed to be tumor-initiating cells capable of tumorigenesis, recurrence, metastasis, and drug resistance, and, like somatic stem cells, are thought to be capable of unlimited self-renewal and, when stimulated, proliferation and differentiation. Here we select cells by expression of a panel of markers to enrich for a population with stem cell-like characteristics. A pane...

Journal: :middle east journal of digestive diseases 0
mehdi mohamadnejad mandana ashrafi kamran alimoghaddam masoud vosough soura mardpour vajiheh azimian

background: during the resent years there has been interest in using bone marrow stem cells to treat liver cirrhosis. however, there is a potential concern for malignant transformation after stem cell therapy. the aim of this study was to evaluate the development of hepatocellular carcinoma (hcc) after autologous bone marrow stem cell transplantation for liver cirrhosis. methods: all the patien...

2016
Hyewon Chung Yu-Hwan Kim Myoung Kwon So-Jin Shin Sang-Hoon Kwon Soon-Do Cha Chi-Heum Cho

OBJECTIVE The identification of cancer stem-like cells is a recent development in ovarian cancer. Compared to other cancer cells, cancer stem-like cells present more chemo-resistance and more aggressive characteristics. They play an important role in the recurrence and drug resistance of cancer. Therefore, the target therapy of cancer stem-like cell may become a promising and effective approach...

2017
Manuel Varas-Godoy Gregory Rice Sebastián E Illanes

Ovarian cancer is one of the most important causes of cancer-related death among women in the world. Despite advances in ovarian cancer treatment, 70-80% of women who initially respond to therapy eventually relapse and die. There is evidence that a small population of cells within the tumors called cancer stem cells (CSCs) could be responsible for treatment failure due to their enhanced chemore...

2013
Irma Virant-Klun Thomas Skutella Matjaz Hren Kristina Gruden Branko Cvjeticanin Andrej Vogler Jasna Sinkovec

The adult ovarian surface epithelium has already been proposed as a source of stem cells and germinal cells in the literature, therefore it has been termed the "germinal epithelium". At present more studies have confirmed the presence of stem cells expressing markers of pluripotency in adult mammalian ovaries, including humans. The aim of this study was to isolate a population of stem cells, ba...

Journal: :iranian biomedical journal 0
علی اکبر موثق پور ali akbar movassagh pour مژده صالح نیا mojdeh salehnia علی اکبر پورفتح ا... ali akbar pourfatollah مسعود سلیمانی masoud soleimani

the aim of this study was to isolate mouse embryonic stem cells from late blastocyst stage embryos and to use them as a model system for the study of hematopoietic induction outside the embryo by coculturing of embryonic stem cells with bone marrow stromal cells. blastocyst stage embryos from pregnant nmri mice were obtained and cultured for 1-2 days in dmem medium. the inner cell masses formed...

2012
Te Liu Yongyi Huang Lihe Guo Weiwei Cheng Gang Zou

OBJECTIVES Stem cell transplantation has been reported to rescue ovarian function in a preclinical mouse model of chemotherapy-induced premature ovarian failure (POF); however, maintaining the survival and self-renewal of transplanted seed cells in ovarian tissues over the long-term remains a troublesome issue. In this study we aimed to determine whether the CD44+/CD105+ human amniotic fluid ce...

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