The aim of the study was to determine, in an experiment performed on conscious gilts, whether an increased amount of progesterone (P4) supplied to the porcine corpus luteum (CL), maintained within a physiological systemic concentration would influence its own secretion. On day 9 of the estrous cycle the jugular veins as well as both ovarian arteries and both ovarian veins were cannulated. In th...

The glycoprotein gp38 is overexpressed in 90% of ovarian carcinomas and recognized by monoclonal antibodies MOv18 and MOv19. This molecule is a high affinity folate binding protein (FBP) and a potential marker for ovarian carcinoma. We have developed a model to investigate the biochemical and biological properties of this folate receptor by transfecting NIH/3T3 cells, which do not endogenously ...

Peroxisome Proliferator Activated Receptors Gamma (PPAR-ᵞ) is a nuclear transcription factor, which Protein receptors for insulin and have significant role in resistance Type 2 Diabetes mellitus addition to the of gene encoded differentiation Adipocyte development Adipose tissue. at present research has been detected substitution silent mutation C T exon 6 PPAR-ᵧ 111 women, including 73 obese w...

In spite of the growing importance of endothelial protein C receptor/active protein C (EPCR/aPC) in tumor biology, their impact on immunological homeostasis remains largely unexplored. The objective of this study was to assess whether soluble plasma endothelial protein C receptor (sEPCR), which is a regulator of circulating aPC, is involved in innate immune response in cancer patients. In the O...

The majority of ovarian tumors eventually recur in a drug resistant form. Using cisplatin sensitive and resistant cell lines assembled into 3D spheroids we profiled gene expression and identified candidate mechanisms and biological pathways associated with cisplatin resistance. OVCAR-8 human ovarian carcinoma cells were exposed to sub-lethal concentrations of cisplatin to create a matched cispl...

background: ovarian hyperstimulation syndrome (ohss) is a recognized complication of ovulation induction, occurring in 1-10% of ivf and embryo transfer cycles. while mild ohss is of no clinical relevance, severe ohss is a life threatening complication. however, the efficacy of prevalent treatments appeared to be limited. we developed a continuous autotransfusion system with an ultrafiltration i...

In previous studies, patients with severe peri-ovarian adhesions have been found to show low pregnancy rates and a poor response to gonadotrophin stimulation during in-vitro fertilization (IVF) treatment. The purpose of this retrospective pharmacokinetic study was to assess the diffusion of exogenous human chorionic gonadotrophin (HCG) in patients with peri-ovarian adhesions by examining the co...

Using cDNA database mining strategies and real-time quantitative reverse transcription-PCR, we identified B7-H4 as a novel gene that is overexpressed in ovarian and breast cancer tissues when compared with normal tissues. The gene encodes a protein of 282 amino acids with a signal sequence, an immunoglobulin domain, and a COOH-terminal hydrophobic transmembrane domain. Immunohistochemistry expe...

Background:Ghrelin, an endogenous ligand for the growthsecretagogue receptor is predominantly produced in the stomach and anexpression of ghrelin has recently been identified in placenta and ovary. OBJECTIVES: Therefore, we decited to measure ovarian ghrelin as quantitative andevaluate the correlation between ghrelin and estrogen during second half ofovine pregnancy. METHODS: The ovarian sample...

An experiment was conducted to investigate the effect of different types of ovarian cycles on reproductive indices and blood metabolites in 61 Holstein cows. Blood samples were taken from each cow between day 12 and day 50 postpartum (PP). Serum progesterone concentrations were measured to determine the onset of luteal function and different types of luteal dysfunctions in cows. Serum glucose, ...