Alopecia areata (AA) is a common hair loss condition characterized by the acute onset of scarring loss. Recently, JAK inhibitors have been used to treat patients with severe AA who do not respond conventional treatments such as glucocorticosteroids, cyclosporine, and diphenylcyclopropenone. Our previous studies showed an alternative effect on follicle cells, decreasing mitochondrial damage infl...

The upper region of the outer root sheath of vibrissal follicles of adult mice contains multipotent stem cells that respond to morphogenetic signals to generate multiple hair follicles, sebaceous glands, and epidermis, i.e., all the lineages of the hairy skin. At the time when hair production ceases and when the lower region of the follicle undergoes major structural changes, the lower region c...

The expression pattern of the immunoglobulin DM-GRASP/BEN gene was studied in the mouse embryo using in situ hybridization. DM-GRASP/BEN is expressed in the spinal cord in a subset of motoneurons expressing Islet-1, and non homogeneously in the dorsal root ganglia (DRG). In contrast, it's expression is homogeneous in the vestibulo-cochlear and trigemminal ganglia. DM-GRASP/BEN is also expressed...

The complications of mechanical lithotripsy include a trapped basket surrounding the stone, fracture of the basket wires or the main operation wire, malfunction of the mechanical lithotriptor crank handle, and ductal injury [1,2]. Impaction of a basket with a captured stone inside occurs occasionally not only during mechanical lithotripsy but also during removal of small stones with non-lithotr...

A specialized quiescent population of hair follicle stem cells, residing in the hair follicle outer root sheath cells (ORSCs), has previously demonstrated pluripotency for differentiation into neural stem cells (NSCs). A previous study indicated that nestin‑positive hair follicle ORSCs are able to differentiate into neurons. However, little has been reported on the isolation of nestin‑negative ...

Transgenic mice that overexpress the anti-apoptotic gene bcl-xL under the control of the keratin 14 promoter have significantly shorter hair than non-transgenic littermates. The deficit in hair length correlated with a decrease in the duration of anagen, the growth phase of the hair cycle. A prolongation in telogen, the resting phase of the hair cycle, was also observed in adult animals. In the...

On numerous occasions duriog examination of material taken from suspected cases of tinea capitis, spindle-shaped cells have been noted along the shafts of both infected and uninfected hairs. These cells usually are attenuated at both ends and occasionally are marked by transverse striations. Superficially they bear some resemblance to the macroconidia produced in culture by Microsporuni cenis, ...

We model diffusion in white matter fascicles as a problem of diffusion in an array of identical thick-walled cylindrical tubes immersed in an outer medium and arranged periodically in a regular lattice. The diffusing molecules have different diffusion coefficients and concentrations (or densities) within the tubes' inner core, membrane, myelin sheath, and within the outer medium. For an imperme...