OBJECTIVES To demonstrate improvements in validated quality-of-life measures for otitis media and gastroesophageal reflux disease (GERD) and an objective score for pediatric reflux obtained by fiberoptic laryngoscopy after treatment with antireflux precautions and therapy in children diagnosed as having either recurrent acute otitis media or otitis media with effusion and GERD. DESIGN Prospec...

BACKGROUND Appropriate use of antibiotics is one of the major issues in medicine today. In most countries, acute otitis media in children is treated with antibiotics; however, the efficacy of antibiotic use in every acute otitis media is a controversial issue. It may be worthwhile looking for special risk groups that benefit more from antibiotic treatment for acute otitis media. Children under ...

Otitis media and mastoiditis occurring in infancy have long been recognized as most troublesome disorders and, of recent years, would appear to be receiving the attention they merit. The frequency of otitis media or otitis media and mastoiditis found both in the infants' wards and in the autopsy room of the Alder Hey Children's Hospital has led to this statistical and clinical enquiry into this...

BACKGROUND Recurrent otitis media is a common problem in young children. Echinacea and osteopathic manipulative treatment have been proposed as preventive measures, but have been inadequately studied. This study was designed to assess the efficacy of Echinacea purpurea and/or osteopathic manipulative treatment (OMT) for prevention of acute otitis media in otitis-prone children. METHODS A rand...

BACKGROUND & OBJECTIVES Microbial infections in the normally sterile environment of the middle ear cavity in patients with otitis media trigger expression of Toll-like receptors (TLRs), cytokines, and nitric oxide. We evaluated the expression levels of TLR-1, -2, -4, -5, -6, and -9, interleukin (IL)-6, -8, -10, and -12, interferon-γ (IFN-γ), tumour necrosis factor-α (TNF-α), and nitric oxide (N...

Experimentelles [(CH3)2SH]+SbF6[2] und SCl3+SbCl6[8] wer­ den nach Literaturvorschriften hergestellt und un­ ter Schutzgas (N2) aufbewahrt. SC12 wird aus den Elementen dargestellt [9] und jeweils frisch destil­ liert eingesetzt. S2C12 (Fluka) wird nach [9] gerei­ nigt und unter Schutzgas aufbewahrt. C H 3SH (Merck) wird ohne weitere Reinigung eingesetzt. Das SO, (Messer-Griesheim) wird über C a...

Objective The objective is to perform a comprehensive review of the literature up to 2015 on the genetics and precision medicine relevant to otitis media. Data Sources PubMed database of the National Library of Medicine. Review Methods Two subpanels were formed comprising experts in the genetics and precision medicine of otitis media. Each of the panels reviewed the literature in their respecti...

BACKGROUND Previously rare A2ML1 variants were identified to confer otitis media susceptibility in an indigenous Filipino community and in otitis-prone US children. The goal of this study is to describe differences in the middle ear microbiome between carriers and non-carriers of an A2ML1 duplication variant that increases risk for chronic otitis media among indigenous Filipinos with poor healt...

This report presents the results of the clinical observation of 96 children under ten years of age with acute otitis media (107 ears) who visited our out-patient clinic from May 1986 to August 1987. The patients were classified into the following three groups according to clinical course: Group 1: 25 cases (26.0%) in which acute inflammatory findings rapidly disappeared and otitis media was cur...

'Trcatmcnt of' acut o)titis media: a controlled studv of 142 childrcn. (an .lled.Assoc7 197(;102:263-. 5 Halstcd C. Ilcpow MI. Balassaniati N, Eimmerich J, \\olinskv E. Otitis mcdia: clinical observations, microbiology, and evaluation of therapy. .lmIDisChild 1968;115:542-51. 6 Howie VM, I'loussard JH. Efficacy ot' fixed combinationi antibiotics versus separate conmponents in otitis media. Clin...