Several materials and techniques have been proposed to improve alveolar wound healing and decrease loss of bone height and thickness that normally follow dental extraction. The objective of this research was the histologic analysis of bone morphogenetic proteins implanted into dental alveoli of rats after extraction. A total of 45 adult male Wistar rats were divided into three groups of 15 anim...

Morselized bone allografts have been used for the treatment of bone stock loss in orthopedic revision surgery with encouraging results. However, several parameters can influence the graft incorporation including the processing treatments. This experimental work used a cavitary bone defect in 90 rabbits to evaluate the sequence of incorporation of three different kinds of morselized bone allogra...

This case study describes the first use of a novel nanosynthetic bone graft, OssDsign™ Catalyst, in Spinal fusion patient. new graft consists nanoscale calcium phosphate containing silicate substitution (5.8wt% silicon) which has been shown to be capable regenerating via endochondral ossification route challenging animal models [1,2], resulting high rates at very early timepoints comparable exi...

In modern biomaterial design the generation of an environment mimicking some of the extracellular matrix features is envisaged to support molecular cross-talk between cells and scaffolds during tissue formation/remodeling. In bone substitutes chemical biomimesis has been particularly exploited; conversely, the relevance of pre-determined scaffold architecture for regenerated bone outputs is sti...

Most allogenic bone graft substitutes have only osteoconductive properties. Developing new strategies to improve the osteoinductive activity of bone graft substitutes is both critical and practical for clinical application. Previously, we developed novel simvastatin-encapsulating poly(lactic-co-glycolic acid) microspheres (SIM/PLGA) that slowly release simvastatin and enhance fracture healing. ...

Introduction: The degree of osseointegration determines the long-term survival and favorable outcomes of orthopedic implant use. Initial fixation is influenced by a number of factors. Hydroxyapatite (HA) coating has a good osteoconductive property and sealing effect on peri implant migration of particles that lead to osteolysis. Furthermore, HA-coated implants show desirable midterm clinical re...