Synovial inflammation plays an important role in the pathogenesis and progress of osteoarthritis (OA). There is an urgent need to find safe and effective drugs that can reduce the inflammation and regulate the pathogenesis of cytokines of the OA disease. Here, we investigated the effect of icariin, the major pharmacological active component of herb Epimedium on human osteoarthritis fibroblast-l...

Mechanical stress plays an important role in the initiation and progression of osteoarthritis. Studies show that excessive mechanical stress can directly damage the cartilage extracellular matrix and shift the balance in chondrocytes to favor catabolic activity over anabolism. However, the underlying mechanism remains unknown. MicroRNAs (miRNAs) are emerging as important regulators in osteoarth...

OBJECTIVES To evaluate the compartmental distribution of knee osteoarthritis (OA) after anterior cruciate ligament reconstruction (ACLR), to determine if patellofemoral or tibiofemoral OA is more strongly associated with knee symptoms and function, and to evaluate the contribution of associated injuries and surgical delay to the development of OA. METHODS This cross-sectional study recruited ...

Introduction Osteoarthritis (OA), also known as degenerative joint disease is the most common form of arthritis and a leading cause of disability worldwide. Osteoarthritis of the knee is one of the five leading cause of physical disability in non-institutionalized elderly men and women. OA knee, along with osteoarthritis of the hip affects the ability to walk and climb stairs more than any othe...

Associations between compartmental distribution of radiographic changes of osteoarthritis (OA), individual features of OA (joint space loss, sclerosis, cyst, osteophyte; each scored 0-3), and presence of synovial fluid calcium particles (calcium pyrophosphate dihydrate (CPPD) crystals identified by polarised light microscopy and other calcium particles by alizarin red positivity (ARP) were soug...

Background: Knee osteoarthritis (OA) is one of the major causes of dysfunction that reduces patients’ quality of life. The aim of current study was to investigate the effectiveness of muscle strengthening exercises on the clinical outcomes of patients with knee OA. Methods: We conducted a single-blind clinical trial on 96 patients with mild to moderate knee osteoarthritis. Patients were random...

Osteoarthritis (OA) is the most common type of arthritis found in the United States [1]. The knee joint is the most frequently affected joint with estimates of 37% of adults over 60 years of age having radiographic evidence of knee OA and 12% having symptoms related to knee OA accompanying radiographic findings [2]. The incidence and prevalence of this debilitating disease combined with lack of...

Osteoarthritis (OA) is the leading cause of function loss and disability among elderly, with significant burden on individual society. It a severe disease for its high rates, morbidity, costs, increased mortality. Multifactorial etiologies contribute to occurrence development OA. The heterogeneous condition poses challenge effective treatment OA; however, emerging treatments are promising bring...

We describe a method to detect osteoarthritis (OA) from knee X-ray images. The detection is based on the thickness of cartilage in knee bone, which correspond to possibility of osteoarthritis. Using our approach better diagnosis treatment can be applied to the patient since a computed automated measurements leads to accurate values so the image segmentation and mathematical morphological operat...