BACKGROUND Oral submucous fibrosis is a chronic, insidious oral mucosal condition affecting the most parts of the oral cavity with high malignant transformation rate triggered by areca nut chewing, nutritional deficiencies, immunologic processes, and genetic predisposition. OSF causes significant hematological abnormalities resulting in anemia and a decrease in serum iron levels. AIM The aim ...

CONTEXT Single cell gel electrophoresis (SCGE) or "comet assay" is a rapid and very sensitive fluorescent microscopic method for detecting various forms of DNA damage at individual cell level. AIMS The aim of the present study was to detect the extent of DNA damage in oral cancer, oral submucous fibrosis (OSMF) and leukoplakia in comparison to normal individual. SETTINGS AND DESIGN A total ...

Background and Objectives:Although the pathogenesis of oral submucous fibrosis (OSMF) has been studied, it remains unclear whether or not this illness might progress to malignancy. The may be better understood by measuring copper zinc levels in tissue serum from these people. Because widespread cultural social usage areca nuts India, a research was conducted investigate their concentrations pop...

background & objectives: oral submucous fibrosis (osmf) is a condition where excessive deposition of dense collagen fibers occurred in the connective tissue of oral mucosa. an alteration of collagen necessitates an in depth understanding of collagen in oral tissues as no breakthrough studies have been reported. therefore the aim was to correlate the clinical, functional and histopathologica...

Verrucous carcinoma (VC) is an exophytic, low-grade, well-differentiated variant of squamous cell carcinoma. It is described as a lesion appearing in the sixth or seventh decade of life that has minimal aggressive potential and, in long-standing cases, has been shown to transform into squamous cell carcinoma. Oral submucous fibrosis (OSMF) is a potentially malignant disorder, and about one-thir...

Submit Manuscript | http://medcraveonline.com to chronic iron deficiency calling it as an Asian analogue of sideropenic dysphagia [3]. OSMF has been predominantly reported among Indians living in India as well as outside, to a lesser extent among other Asiatics and, sporadically, among Europeans. With a reported prevalence ranging up to 0.4% in Indian rural populations [4], several million indi...

Areca quid chewing related oral mucosal lesions are potential hazard to a large population worldwide. Commercially freeze dried products such as pan masala, Guthka and mawa have high concentration of areca nut per chew and appear to cause OSMF more rapidly than by self prepared conventional betel quid that contain smaller amounts of areca nut. These chemical appear to interfere with the molecul...

‘Vidari’ is a crippling fibrotic disorder affecting mouth commonly seen in India and South East Asia. It’s always optimum highly desirable to beat oral submucous fibrosis(OSMF) before it becomes cancer. OSMF huge dilemma for clinicians worldwide specifically south east Asia due elusive pathogenesis. The main characterstic of the build up fibrous tissue sub mucosal layer mouth, which can lead lo...

OBJECTIVE To estimate and compare the levels of serum copper and iron among subjects with oral submucous fibrosis (OSMF) of different clinical stages and healthy controls. STUDY DESIGN Study sample comprised of 50 patients clinically diagnosed with OSMF and 50 healthy controls who were matched for age and gender. OSMF patients were categorised by clinical staging. Serum estimation of copper a...

Oral cancer generally progresses from precancerous lesions such as leukoplakia (LK), lichen planus (LP) and oral submucous fibrosis (OSMF). Since few of these precancers progress to cancers; it is worth to identify biological molecules that may play important roles in progression. Here, expression deregulation of 7 miRNAs (mir204, mir31, mir31*, mir133a, mir7, mir206 and mir1293) and their poss...