Oncostatin M (OSM) is a multifunctional cellular regulator acting on a wide variety of cells, which has potential roles in the regulation of gene activation, cell survival, proliferation and differentiation. Previous studies have shown that OSM can induce morphological and/or functional differentiation and maturation of many tumor cells. However, the action of OSM on the induction of differenti...

Mediators in the synovial fluid are thought to play a major role in osteoarthritic cartilage turnover. The purpose of the current study was to investigate the role of oncostatin M (OSM) in osteoarthritis (OA) by evaluating the presence of the cytokine and its receptors in the OA joint and interfering with its activity in synovial fluid co-cultured with cartilage explants. OSM levels were increa...

Although cyclic nucleotide-gated channels mediate sensory transduction in olfaction and vision, other forms of sensory transduction are independent of these channels. Caenorhabditis elegans cyclic nucleotide-gated channel mutants respond normally to some olfactory stimuli and to osmotic stimuli, suggesting that these chemosensory responses use an alternative sensory transduction pathway. One ge...

This paper describes the results of an analysis of the OpenStreetMap (OSM) database for the United Kingdom (UK) and Ireland (correct to April 2011). 15, 640 OSM ways (polygons and polylines), resulting in 316, 949 unique versions of these objects, were extracted and analysed from the OSM database for the UK and Ireland. In our analysis we only considered “heavily edited” objects in OSM: objects...

During and after transendothelial migration, neutrophils undergo a number of phenotypic changes resulting from encounters with endothelium-derived factors. This report uses an in vitro model with human umbilical vein endothelial cells and isolated human neutrophils to examine the effects of two locally derived cytokines, granulocyte (G)-macrophage (M) colony-stimulating factor (GM-CSF) and G-CS...

A central assumption of models proposed to explain object substitution masking (OSM) is that the phenomenon arises only when attention is distributed across several possible target locations. However, recent work has questioned the role of attention in OSM, suggesting instead that ceiling effects might explain the apparent interaction between spatial attention and masking. Here the authors repo...

A novel usability evaluation technique, Ontological Sketch Modelling (OSM), was applied to the analysis of systems used within a complex work setting, namely emergency medical dispatch. OSM focuses on the structure of the domain in question and the devices which are applied to that domain, in order to reason about the quality of fit between the two. This analysis shows how OSM can be used to id...

Floods are considered the most common and devastating type of disasters world-wide. Therefore, flood management is a crucial task for municipalitiesa task that requires dependable information to evaluate risks and to react accordingly in a disaster scenario. Acquiring and maintaining this information using official data however is not always feasible, especially for smaller municipalities. This...

Nephronectin (Npnt), also called POEM, is an extracellular matrix protein considered to play critical roles as an adhesion molecule in the development and functions of various tissues, such as the kidneys, liver, and bones. In the present study, we examined the molecular mechanism of Npnt gene expression and found that oncostatin M (OSM) strongly inhibited Npnt mRNA expression in MC3T3-E1 cells...

Open Student Modeling (OSM) is a popular technology that makes traditionally hidden student models available to the learners for exploration. OSM is known for its ability to increase student engagement, motivation, and knowledge reflection. A recent extension of OSM known as Open Social Student Modeling (OSSM) attempts to enhance cognitive aspects of OSM with social aspects by allowing students...