نتایج جستجو برای: ortho acylation

تعداد نتایج: 9489  

Journal: :Lab on a chip 2009
Masahiro Sato Keiichiro Matsushima Hajime Kawanami Maya Chatterjee Toshiro Yokoyama Yutaka Ikuhsima Toshishige Maro Suzuki

A high-speed, highly efficient chemoselective N-acylation by anhydride was achieved in the absence of catalyst for exothermic (DeltaH>0) and endothermic (DeltaH<0) acylation of various amines and anilines with the microreaction system of ambient water (micro-onH2O) and subcritical water (micro-subH2O), where the desired N-acylated products are chemoselectively obtained with high yield(s) and ex...

Journal: :Journal of Synthetic Organic Chemistry, Japan 2019

2016
Benjamin F Rahemtulla Hugh F Clark Martin D Smith

A catalytic enantioselective route to C1 - and C2 -symmetric 2,2'-spirobiindanones has been realized through an intramolecular enolate C-acylation. This reaction employs a chiral ammonium counterion to direct the acylation of an in situ generated ketone enolate with a pentafluorophenyl ester. This reaction constitutes the first example of a direct catalytic enantioselective C-acylation of a ket...

2016
Hong Jiang Xiaoyu Zhang Hening Lin

Tumor necrosis factor-α (TNF-α) is a proinflammation cytokine secreted by various cells. Understanding its secretive pathway is important to understand the biological functions of TNF-α and diseases associated with TNF-α. TNF-α is one of the first proteins known be modified by lysine fatty acylation (e.g. myristoylation). We previously demonstrated that SIRT6, a member of the mammalian sirtuin ...

2012
Di Chen Ai-Ping Zhang Chuan-Fu Liu Run-Cang Sun

Bagasse acetate butyrates were prepared homogeneously in 1-butyl-3methylimidazolium chloride ([C4mim]Cl) ionic liquid from ball-milled sugarcane bagasse by acylation with acetic anhydride and butyric anhydride. The parameters, including reaction temperature, reaction time, feeding method of adding anhydrides, the dosage of total anhydrides to SCB, and the molar ratio of acetic anhydride to buty...

Journal: :Current eye research 2005
Pauline Cho Sin Wan Cheung Marion Edwards

PURPOSE Myopia is a common ocular disorder, and progression of myopia in children is of increasing concern. Modern overnight orthokeratology (ortho-k) is effective for myopic reduction and has been claimed to be effective in slowing the progression of myopia (myopic control) in children, although scientific evidence for this has been lacking. This 2 year pilot study was conducted to determine w...

Journal: :Environmental science & technology 2008
Andrew S Campbell Yan Yu Steve Granick Andrew A Gewirth

We compare the association of an ortho-substituted and a planar PCB (polychlorinated biphenyls PCB-52 and PCB-77, respectively) with single-component phospholipid bilayers terminated with phosphocholine headgroups. First, fluorescence correlation spectroscopy (FCS) studies of diffusion on supported fluid-phase DLPC show that the ortho-substituted PCB diffuses more slowly, indicating either comp...

Journal: :The Biochemical journal 1995
A Yamashita M Watanabe T Tonegawa T Sugiura K Waku

When [14C]arachidonoyl-CoA was incubated with crude extracts of rat liver microsomes, [14C]arachidonic acid was incorporated into many proteins, suggesting that modification of these proteins with fatty acid, i.e. acylation, occurred. Using a [14C]arachidonyl-CoA labelling assay, 50 and 53 kDa proteins were purified from rat liver microsomes to near homogeneity by sequential chromatography on R...

Journal: :The Journal of biological chemistry 1994
R S Johnson H Ohguro K Palczewski J B Hurley K A Walsh T A Neubert

Heterogeneous N-terminal glycine acylation recently has been reported for two proteins involved in visual signal transduction. Similar N-acylations have typically involved only myristate; however, none of the previously examined proteins were isolated from retinas. To determine whether heterogeneous N-acylation is tissue-specific or protein sequence-specific, the N-terminal modifications of the...

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