Orotidylate decarboxylase has been purified approximately 300-fold from human erythrocytes. It was shown to exist in three molecular weight forms, a probable monomer of molecular weight 62,000, a dimer, and a tetramer. Conversion of the monomer to higher molecular weight forms was associated with increased stability to thermal inactivation and was promoted by a number of low molecular weight co...

and thioacetamide caused similar changes in the nuclear RNA metabolism of precancerous rat liver, and whether these changes could be distinguished from those caused by the weak hcpatocarcinogen 4'-methyl-4-dimethylaminoazobenzene (4'Me-DAB). Carcinogens were administered by intraabdominal injection or by feeding in semisynthetic diets. Their effects on nuclear RNA synthesis and nuclear RNA conc...

A chitosan (CS)-orotic acid salt (CS-OT) was prepared, and the release of orotic acid (OT) from CS-OT as well as the adsorption of bile acids by CS-OT was investigated in vitro. The amount of OT released from CS-OT was about 2-2.7 micromol/mg CS-OT and this changed depending on the species of CS. CS-OT also adsorbed bile acids and the amount increased incrementally according to the number of am...

An ideal system for examining the relationship between ribonucleic acid (UNA) and deoxyribonucleic acid (DNA) metabolism in animals would be a tissue where synchronous cell division occurs. Isotopie tracer studies (9, 22, 25) and determina tion of the DNA content per nucleus in the liver cells of partially hepatectomized rats (25, 26, 83) have suggested that in animals the most feasible approac...

Some scholars caution that long-term ad libitum feeding with probiotic fermented food poses potential health risks to baby animals. We conducted a feeding experiment to investigate the influence of ad libitum feeding of pre-and post-weaned piglets with a Bacillus subtilis fermented diet on the gut microbiome, gut metabolomic profiles, bile acid metabolism, proinflammatory cytokines and faecal c...