background: the pathogenesis of ethanol in the liver and kidney is associated with an increase in free radicals and oxidative stress that leads to structural and functional abnormalities in these vital organs. methods: forty-eight male wistar rats were placed in eight groups and were treated as follows: control group (normal saline), group of ethanol (4 g/ kg), three doses of ardeh and honey co...

objective: inflammation and oxidative stress is considered to have a crucial role in induction of nephropathy. curcuma longa (c. longa) and nigella sativa (n. sativa) have anti-inflammatory and antioxidant effects. this study was designed to investigate the effect of mixed hydro-alcoholic extract of n.sativa and c. longa on the oxidative stress induced by adriamycin (adr) in rat kidney. materia...

objective(s):the present study was undertaken to determine the effects of acute exposure to malathion on oxidative stress and cytotoxic potential of anticholinesterase insecticide, malathion in reproductive toxicology of adolescent male mice. materials and methods: thirty two adolescent male mice at pubertal age were treated with 500 mg/kg body weight (bw) of malathion for three days. after exp...

objective(s) the aim of this study was to evaluate the effects of regular exercise in preventing diabetes complication in the hippocampus of streptozotocin (stz)-induced diabetic rat. materials and methods a total of 48 male wistar rats were divided into four groups (control, control exercise, diabetic and diabetic exercise). diabetes was induced by injection of single dose of stz. exercise was...

background there is currently great concern about the possible adverse effect of microwave radiation from cell phones. in addition, noise is one of the physical pollutants of modern societies. objectives the present study aimed to examine the separate and simultaneous effects of cell phone microwaves, noise, and their effects on sperm parameters and total antioxidant capacity in adult male rats...

OBJECTIVE To determine the efficiency of selenium and/or vitamin E to alleviate lung oxidative damage induced by dimethoate, an organophosphorus compound. METHODS Adult Wistar rats were exposed during 30 days either to dimethoate (0.2 g/L of drinking water), dimethoate+selenium (0.5 mg/kg of diet), dimethoate+vitamin E (100 mg/kg of diet), or dimethoate+selenium+vitamin E. RESULTS Exposure ...

objectives we aimed to investigate whether there is renal injury and its relationship with oxidative stress after intraperitoneal injection of α-ama in mice experimental poisoning models. materials and methods there were 37 male balb/c laboratory mice treated with α-ama, according to the study groups: control group (n = 7); low dose (0.2 mg/kg) (n = 10); moderate dose (0.6 mg/kg) (n = 10), and ...

many studies indicate that oxidative stress is involved in the pathophysiology of neurodegenerative diseases. oxidative stress can induce neuronal damages, modulate intracellular signaling and ultimately leads to neuronal death by apoptosis or necrosis. to review antioxidants preventive effects on oxidative stress and neurodegenerative diseases we accumulated data from international medical jou...

objective(s): exposing to stress may be associated with increased production of reactive oxygen species (ros). therefore, high level of oxidative stress may eventually give rise to accumulation of oxidative damage and development of numerous neurodegenerative diseases. it has been presented that brain-derived neurotrophic factor (bdnf) supports neurons against various neurodegenerative conditio...

o bjective : increased levels of oxidative stress markers in periodontitis have been reported by recent studies. malondialdehyde (mda) and superoxide dismutase (sod) are both in- creased during oxidative stress. the aim of this study was to detect and measure the level of oxidative stress markers in peri-implant crevicular fluid (picf). their correlation with peri-implant clinical parameters wa...