Central diabetes insipidus (CDI), which is characterized by polyuria and polydipsia, is caused by a deficiency of the antidiuretic hormone arginine vasopressin (AVP). While CDI is treated with desmopressin, an analogue of AVP, the intranasal formulation is inconvenient and CDI patients reportedly prefer the oral formulation to the intranasal one. In Japan, intranasal desmopressin had been the o...

AIM: This study aimed to make corncobs the basic material for manufacture of microcrystalline cellulose. METHODS: Manufacture corncob cellulose microcrystals (CCMs) by isolating alpha-cellulose from corncobs, then hydrolyzed with HCl 2.5 N. The yield CCMs 14.51% can be used as orally disintegrating tablet (ODT) and has similarities Avicel standard comparison. RESULTS: Both organoleptic results ...

Strabismus surgery in pediatric patients is associated with a high incidence of postoperative nausea and vomiting (PONV). Ondansetron disintegrating tablets (ODT), an oral freeze-dried formulation of the 5-HT(3) antagonist, are well-tolerated and have been shown to reduce chemotherapy-induced vomiting. The purpose of this study was to assess the efficacy of the ODT in preventing postoperative v...

BACKGROUND Lamotrigine is an anticonvulsant drug indicated for the maintenance treatment of bipolar I disorder and for various types of epilepsy. An orally disintegrating tablet (ODT) of lamotrigine was developed to provide a formulation option that might increase patient convenience and satisfaction. METHODS Subjects with mood disorders who reported difficulty swallowing currently prescribed...

Objective of this study was to formulate directly compressible orally disintegrating tablets of Cinnarizine with sufficient mechanical integrity, content uniformity, and acceptable palatability to assist patients of any age group for easy administration. Effect of varying concentrations of different superdisintegrants such as Agar, gum karaya, platago ovata on disintegration time was studied. T...