Orally disintegrating tablets (ODTs) are capable of turning quickly into a liquid dosage form in contact with the saliva, thus possessing the advantages of both the solid dosage forms particularly stability and liquid dosage forms specially ease of swallowing and pre-gastric absorption of drug. The aim of this study was to prepare a novel matrix-type buccal fast disintegrating ibuprofen tablet ...

10.2217/14750708.2.3.349 © 2 part of The introduction of the 5-HT1B/1D agonist sumatriptan in 1991 marked a significant advance in the management of migraine. Sumatriptan was the first migraine pharmacotherapy designed to selectively target the neurovascular origin of migraine pain. Sumatriptan was introduced in several formulations – injection, nasal spray, conventional tablet or suppository. ...

---------------------------------------------------RECENT MAJOR CHANGES-------------------------------------------------­ Indications and Usage, Schizophrenia/Adolescents (1.1) 08/2007 Indications and Usage, Bipolar Mania/Pediatrics (1.2) 08/2007 Dosage and Administration, Schizophrenia/Adolescents (2.1) 08/2007 Dosage and Administration, Bipolar Mania/Pediatrics (2.2) 08/2007 -----------------...

Development of a lyophilized orally disintegrating tablet (ODT) that enhanced the in vitro dissolution and in vivo absorption of nimesulide (NM), a drug with poor solubility and poor bioavailability, is presented. The ODTs were prepared by freeze-drying an aqueous dispersion of NM containing a matrix former, a sugar alcohol, and a collapse protectant. In addition, different disintegration accel...

Fast-dissolving drug-delivery systems were first developed in the late 1970s as an alternative to tablets, capsules, and syrups for the patients of pediatric and geriatric who faces difficulties in swallowing conventional oral solid dosage forms. On the basis of this need, a variety of orally disintegrating tablet (ODT) formats were commercialized. Most ODT products were formulated to disintegr...

AIM: This study aimed to make corncobs the basic material for manufacture of microcrystalline cellulose. METHODS: Manufacture corncob cellulose microcrystals (CCMs) by isolating alpha-cellulose from corncobs, then hydrolyzed with HCl 2.5 N. The yield CCMs 14.51% can be used as orally disintegrating tablet (ODT) and has similarities Avicel standard comparison. RESULTS: Both organoleptic results ...