This report shows the therapeutic benefit of HEP1 (human ezrin peptide 324-337; TEKKRRETVEREKE) monotherapy of hepatitis C virus (HCV) infection in HIV infected patients in two clinical studies. In the Pilot Study I, 16 of 18 patients responded well to the treatment with significant reductions of HCV viral load and a normalization of serum liver enzymes. In 8 of 18 patients, HCV RNA became unde...

A 4 year old boy with Hodgkin's lymphoma was admitted to the paediatric ward with meningoencephalitis dominated by generalised seizures and motor aphasia. Serum IgM specific antibodies to West Nile virus were positive. In view of ongoing neurological deterioration and immunocompromised state he was treated with oral ribavirin for 14 days. A gradual improvement was noted within two weeks of ther...

In the article, “Assessment of hepatocellular carcinoma risk based on peg-interferon plus ribavirin treatment experience in this new era of highly effective oral antiviral drugs”, which appeared in Volume 96, Issue 1 ofMedicine, the information about the study funding appeared incorrectly as “This study was supported by an Inha University Hospital grant.” It should have appeared as “This study ...

BACKGROUND The standard treatment for hepatitis C virus (HCV) infection is interferon, which is administered subcutaneously and can have troublesome side effects. We evaluated sofosbuvir, an oral nucleotide inhibitor of HCV polymerase, in interferon-sparing and interferon-free regimens for the treatment of HCV infection. METHODS We provided open-label treatment to eight groups of patients. A ...

1498 CMAJ, September 18, 2012, 184(13) © 2012 Canadian Medical Association or its licensors A47-year-old black woman with chronic hepatitis C (genotype 4) was referred for hyperpigmentation of the tongue. She was a nonsmoker. Eight weeks after treatment with weekly injections of subcutaneous pegylated interferon α-2a and daily oral ribavirin was started for hepatitis C, asymptomatic dark brown ...

BACKGROUND AND PURPOSE For the retreatment of chronic hepatitis C patients relapsing after, or non-responsive to, previous interferon therapy, the efficacy of combination therapy with interferon alfa plus ribavirin is superior to interferon alone. The aim of this study was to determine whether prolonged interferon alfa treatment after 24-week combination therapy can further increase the efficac...

INTRODUCTION Hepatitis C virus (HCV) infections remain an increasingly prevalent and emergent health problem worldwide, causing a wide spectrum of liver diseases. Combination therapy with pegylated interferon (PEG-IFN) of peginterferon alfa-2a and oral ribavirin is currently recognized as the standard treatment of chronic HCV infection. Several complex immunological mechanisms are involved duri...

BACKGROUND Approximately one-third of patients with chronic hepatitis C virus infection have persistently normal liver enzymes reflected by a normal serum alanine transaminase (ALT). Data with regards the efficacy and safety of treatment in patients chronically infected with Hepatitis C virus genotype 4 and normal serum ALT are limited. AIM To evaluate the efficacy and safety of peginterferon...

Respiratory Syncytial Viral Infection is one of the most common viral infections in respiratory airways and more infants, younger children some adults. Although ribavirin has been used management RSV infection, many effective drugs are still under development. Also, structured based drug design using computational tools shifted paradigm discovery. The fusion core (RSV) structure crucial for its...