A single cycle of rituximab for the treatment of severe pemphigus. Treatment of severe pemphigus with rituximab: report of 12 cases and a review of the literature. Clinical efficacy of different doses of ritux-imab in the treatment of pemphigus: a retrospective study of 27 patients. Rituximab for treatment-refractory pemphigus and pemphigoid: a case series of 17 patients. in autoim-mune bullous...

PURPOSE Pemphigus, defines a group of disorders in autoimmune etiology which could be life-threatening and clinical manifestations are mainly epithelial blistering affecting cutaneous and/or mucosal surfaces including oral mucosa. The aim of our study is to evaluate the clinical appearance of pemphigus with oral involvement by reported 15 pemphigus cases. MATERIAL AND METHODS This retrospecti...

Pemphigus is a group of autoimmune blistering diseases. There had been abundant evidence that antibodies against components within the desmosomes were responsible for its pathogenesis. The major antigens in pemphigus vulgaris and pemphigus foliaceus are desmoglein 3 (130 kDa) and desmoglein 1 (160 kDa) respectively. They are glycoproteins belonging to the cadherin family and form part of the tr...

Bullous Pemphigus and Pemphigus Vulgaris are autoimmune dermatological illnesses that manifest particularly in adults. They are characterized by the presence of auto-antibodies against specific structures of the skin and mucous membranes marked by the appearance of epithelial beads. While Bullous Pemphigus is of limited duration and is generally benign, in contrast Pemphigus Vulgaris is an illn...

Pemphigus vulgaris is a chronic autoimmune mucocutaneous disease that initially manifests in the form of intraoral lesions, which spread to other mucous membranes and the skin. The etiology of pemphigus vulgaris is still unknown, although the disease has attracted considerable interest. The pemphigus group of diseases is characterized by the production of autoantibodies against intercellular su...

BACKGROUND Pemphigusis a bullous, rare and chronic autoimmune disease. There are two major forms of pemphigus: vulgaris and foliaceus. Epidemiological data and clinical outcome in patients diagnosed in the Brazilian Amazon states are still rare. OBJECTIVES To study the occurrence of the disease during the study period and analyze the epidemiological profile of patients, the most common subtyp...

Background: Pemphigus vulgaris, the most common form of pemphigus, is due to the production of auto-antibodies directed against adhesion molecules (desmoglein 1 and 3) that belong to the cadherin family. B cell-activating factor of the TNF family (BAFF) and a proliferation-inducing ligand (APRIL) may play a significant role in autoimmune diseases such as pemphigus vulgaris. Only a few studies h...

Parotitisis the inflammation of parotid gland and frequently due to bacterial viral infections, but mechanical obstruction parotitis ductus, Sjogren’s disease, other xerostomia etiologies, sarcoidosis, tuberculosis, oral ulcerations, drugs can also cause though less frequently. Pemphigus vulgaris patients may theoretically be at an increased risk for salivary inflammations because various reaso...

studies on hla-g, a nonpolymorphic antigen of non-classical hla class i, is of basic and clinical significance. in the present study, the expression of hla-g proteins in the human skin tissue sections of normal and autoimmune pemphigus vulgaris (pv) individuals were investigated using monoclonal antibodies. the antibodies recognized both membrane-bound and soluble isoforms of hla-g. rt-pcr was ...