PURPOSE Previous studies showed that a single oral administration of a synthetic ketone ester (1,3-butanediol acetoacetate diester, BD-AcAc2) could elevate blood ketones with promising acute anti-epileptic effects. The aim of the present work was to evaluate the tolerability of a prolonged administration of BD-AcAc2 and the anti-epileptic efficacy of such treatment. METHODS The threshold for ...

Aim. To investigate the effects of HS-1200 on liver tumorigenesis and liver function in a diethylnitrosamine- (DEN-) induced hepatocellular carcinoma (HCC) rat model. Methods. Rats were randomly assigned into five groups: control, HS-1200, HCC, HCC + low dose HS-1200, and HCC + high dose HS-1200 groups. Rat HCC model was established by intraperitoneal injection of DEN. And rats were given HS-12...

Background: The excessive use of artificial sweeteners now a days just to lose weight and remain fit due other reasons without knowing its effects on liver gave me thought conduct this study see whether they are safe or not for health. Aim: To the Aspartame Sucralose size rat hepatocytes compare their choose relatively sweetener routine use. Methods: Fifty adult Wistar albino rats used in were ...

The acute and subacute hypoglycemic and antihyperglycemic effects of drinkable ripe onion juice (Commercial product name is "Black Onion Extract") were investigated in normal and streptozotocin-induced diabetic rats. For tests of acute and subacute hypoglycemic effects, ripe onion juice (5 and 15 mL/kg b.w.) was administered by oral gavage to normal Sprague Dawley rats and measurements of fasti...

OBJECTIVES Pancreas pathology in subacute endosulfan toxicity and the effect of vitamin C in rabbits were studied. METHODS : Twenty-four rabbits in 4 groups were used. The rabbits in group END were given a daily sublethal dose (1 mg/kg of body weight) of endosulfan in corn oil by oral gavage for 6 weeks. Group END+C received the same dose of endosulfan and also vitamin C (20 mg/kg) every othe...

The aim of this study was to investigate the effect of tart cherry juice on serum uric acid levels, hepatic xanthine oxidoreductase activity and two non-invasive biomarkers of oxidative stress (total antioxidant capacity and malondialdehyde concentration), in normal and hyperuricemic rats. Tart cherry juice (5 ml/kg) was given by oral gavage to rats for 2 weeks. Allopurinol (5 mg/kg) was used a...

BACKGROUND Oral ferrous iron therapy may reinforce intestinal inflammation. One possible mechanism is by catalyzing the production of reactive oxygen species. We studied the effects of low-dose oral ferrous fumarate on intestinal inflammation and plasma redox status in dextran sulfate sodium (DSS)-induced colitis in rats. METHODS Forty male Wistar rats were divided into 5 groups: no intervent...

UNLABELLED Theme: Transition of care. INTRODUCTION Oral feeding is one of the hardest steps for premature infants after respiratory independence and is a challenge for nurses in neonatology. OBJECTIVES To know the characteristics of preterm infants, essential for oral feeding; to know the nurses' opinion on nursing interventions, that promote the transition of gavage feeding for oral feedin...

Methods 30 New Zealand white rabbits were randomly divided into saline control group(group A) and two treatment groups of 3ml/kg(group B) and 10ml/kg(group C) of Xuebijing oral solution.All the rabbits were treated with PQ at 35mg/kg through intraperitoneal injection, which would build the model of acute poisoning. Group B and C were treated by gavage with 3ml/kg and 10ml/kg of Xuebijing oral s...