BACKGROUND We investigated the hypothesis that long-term use of oral contraceptives (OCs), in particular high-dose OCs, could postpone age at menopause. METHODS Data was used from 8701 women who participated in a breast cancer screening programme in Utrecht (DOM-3 cohort), and who did not use hormone replacement therapy (HRT) or OCs in the 4 years prior to their last menses. Data on OC-use, m...

introduction: the pilgrimage to ka’beh (god’s house in mecca) is a special opportunity in the life of most muslims. female pilgrims try to postpone menstruation during the pilgrimage by taking hormonal medicines. however, women are seen in this disorder. this paper aimed to determine the frequency of menstrual disorders and related factors among female pilgrims of umrah mufradah in 2012.methods...

PURPOSE The 5 year survival rates for oral cancer have not changed in the last 50 years. A simple intra- and extra-oral examination provided by health care professionals could help to reduce morbidity and mortality of oral cancer. This study focused on Texas dental hygienists' performance of oral cancer screenings (OCS) and factors that influenced their performance of this examination. METHO...

BACKGROUND Oral contraceptives (OCs) have been available in Canada for over 50 years and are the most commonly used method of reversible contraception. OCs have evolved over time, with decreasing estrogen doses, new progestins, and different dosing regimens. Detailed data about OCs use among Canadian women are lacking. DATA AND METHODS Data from Statistics Canada's 2007/2009 and 2009/2011 Can...

We publish in this issue an authoritative and timely opinion on the effects of third-generation oral contraceptives on the incidence of venous thromboembolism (VTE) and acute myocardial infarction (AMI) among users (Spitzer, 1997). The author is a highly experienced and leading epidemiologist in the field, and his conclusions are disturbing. He details what seems to be serious misinterpretation...

Background Several recent studies have suggested that oestrogen exposure may increase the risk of prostate cancer (PCa). Objectives To examine associations between PCa incidence and mortality and population-based use of oral contraceptives (OCs). It was hypothesised that OC by-products may cause environmental contamination, leading to an increased low level oestrogen exposure and therefore hig...

Background and objectives: In the evolutionary past, women spent most of their reproductive lives either pregnant or in lactational amenorrhea, and rarely menstruated. The current pattern of frequent menses, and the associated increase in endogenous hormonal exposure, has been implicated in the current breast cancer epidemic. It is not known, however, whether oral contraceptives further increas...

CYP2C9-dependent drug metabolism is subject to large interindividual variation. To some extent, this is explained by genetic polymorphism with expression of enzyme variants that differ in catalytic activity. The aim of this study was to characterize the variation in CYP2C9 phenotype in relation to genotype, with further analysis of the CYP2C9 gene in metabolic outliers. A study population of 12...

Fibrin metabolism is influenced by many factors. The velocity of fibrin formation, genetic polymorphisms, fibrinolytic features and the structure of the fibrin clot are determinants of fibrin turnover. Oral contraceptives (OCs) have significant impact on the haemostatic system, by increasing the concentration of coagulation factors, plasminogen and tissue plasminogen activator activity, and dec...

conclusions the risk of ra increased with delayed menarche, advanced maternal age at first delivery and early age at menopause. however, longer duration of breast-feeding, parity, large number of children and consumption of ocs were found as protective independent variables against ra. methods this case-control study was conducted on 231 patients with ra and 238 controls among females aged 26 -...