Methotrexate (MTX) being the widely used biologic agent is used to treat severe and/or disabling psoriasis but precipitates various side effects on oral therapy. Encapsulating methotrexate in flexible liposomes for delivery through skin could lead to better therapeutic action and reduce side effects. In order to screen out the various factors during liposome formulation development, Plackett Bu...

In this study, we investigated the implementation of an automatic procedure for optimizing thermoformed thinwalled structures. Such objects are created in great numbers, especially in the food packaging industry. The methodology for the optimal design of such structures is based on the use of a parameterized geometry model created within an interactive design environment. By varying the paramet...

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Introduction Imagine, for a second, a doorman that behaves as automatic doors do. He does not acknowledge you when you pass by, or approach. He gives no hint which door can or will open—until you wander within 10 feet of the door, whereupon he flings the door wide open. If you arrived after hours, you might stand in front of the doors for awhile before you understood that the doors are locked, ...