The major vault protein (MVP) is the predominant constituent of ubiquitous, evolutionarily conserved large cytoplasmic ribonucleoprotein particles of unknown function. Vaults are multimeric protein complexes with several copies of an untranslated RNA. Double labeling employing laser-assisted confocal microscopy and indirect immunofluorescence demonstrates partial colocalization of vaults with c...

Barrel Shifter plays an important role in the data shifting and data rotation. It is having application in many areas. The Barrel Shifter is mainly use for the simplification of the data shifting. The Arithmetic and the Logical Shifters can also be replaced by the Barrel Shifter Because with the rotation of the data it also provide the application the data right, left shifting either arithmetic...

In vaulting a gymnast must generate sufficient linear and angular momentum during the approach and table contact to complete the rotational requirements in the post-flight phase. This study investigated the optimization of table touchdown conditions and table contact technique for the maximization of rotation potential for forwards rotating vaults. A planar seven-segment torque-driven computer ...

The aim of the reconstruction of the vaults is to achieve a maximum of fidelity to the original, which must not be limited to the appearance, but has to regard also the structural character, the "microstructure", and especially the traditional building procedure. The Persian art of vault construction is unique and deserves to be preserved and recorded as cultural heritage, apart from the struct...

arches and vaults are of the most important parts of traditional buildings of iranian architecture. in the traditional architecture of iran, before oil was discovered, fuel (such as wood) was one of the high-ranking issues. therefore, iranian traditional architects did their best to reduce the use of wood. there was however, a revival of the use of brick in construction. qomi-poosh technology i...

Vaults are nanoscale, ribonucleoprotein capsules (41 nm × 41 nm × 72.5 nm [1]) comprised primarily of 96 self-assembled copies of one 96 kDa protein, termed MVP (major vault protein). When deposited on polylysine-coated mica and imaged using cryoelectron microscopy, vaults appear to “open” into flower-like structures with eight rectangular ‘petals’ [2]. Upon closer examination, each ‘flower’ co...

Despite efforts for over 25 years, de novo protein design has not succeeded in achieving the TIM-barrel fold. Here we describe the computational design of four-fold symmetrical (β/α)8 barrels guided by geometrical and chemical principles. Experimental characterization of 33 designs revealed the importance of side chain-backbone hydrogen bonds for defining the strand register between repeat unit...

When the number of data used for an identification experiment is small, the data contain transient effects and these effects contribute to the accuracy of the identified model. Consequently, when designing the optimal input signal for an identification experiment in the case of small data set, these transient effects have to be taken into account. In this paper, we present a methodology for opt...