Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: a rando-mized, placebo-controlled trial. et al. A randomized placebo-controlled trial of idebenone in Leber's hereditary optic neuropathy. Brain (this issue) 2011. Koilkonda RD, Guy J. Leber's hereditary optic neuropathy – gene therapy: from benchtop to bedside. Do idebenone and vitamin therapy shorten the time to...

First proposed by De Wecker! in 1872 as a treatment for neuroretinitis, optic nerve sheath decompression (or fenestration) is an operation that has caused much controversy. This surgical therapy was not seriously considered until Davidson" and Smith, Hoyt, and Newton" reintroduced it in 1969 as an alternative therapy for chronic disk edema. Over the next 19 years, however, only about 60 cases o...

DOS Times Vol. 11, No. 8 February, 2006 These disorders are often grouped together as they cause a syndrome characterized by papillomacular bundle damage, central or cecocentral scotoma, and reduction of color vision. The anterior visual pathway is susceptible to damage from toxins or nutritional deficiency (Table 1). Both toxicity and malnutrition, acting either independently or together, have...

Sir, We read with great interest the article by Gelfand et al. (2012) in the June issue of Brain. The authors described in detail vacuolar macular changes in the inner nuclear layer of patients with multiple sclerosis. This ‘microcystic macular oedema’ was associated with decreased visual acuity and a higher disability score. We found similar microcysts in the macular inner nuclear layer of a 1...

A 57-year-old woman experienced bilateral acute ischemic optic neuropathy after spine surgery. Routine MR imaging sequence, T2-weighted image, showed subtle high signal intensity on bilateral optic nerves. A contrast-enhanced T1 weighted image showed enhancement along the bilateral optic nerve sheath. Moreover, diffusion-weighted image (DWI) and an apparent diffusion coefficient map showed mark...

BACKGROUND We present a case of a patient initially presenting with multifocal choroiditis (MFC) in one eye. She subsequently developed lesions most consistent with punctate inner choroidopathy (PIC) in the contralateral eye, followed by acute vision loss from retrobulbar optic neuropathy. Optic neuropathy has been well described in the setting of MFC. There is, however, only one report of its ...

The development of biopharmaceutical agents, including the interferons (IFN), offers new treatment options for a wide range of medical conditions. Such advancements, however, have not come without risk to patients. Optic neuropathy in the setting of IFN therapy has been previously documented and is usually attributed to anterior ischaemic optic neuropathy; however, the pathophysiology remains p...

PURPOSE Tuberculous optic neuropathy may follow infection with Mycobacterium tuberculosis or administration of the bacille Calmette-Guerin. However, this condition is not well described in the ophthalmic literature. METHODS Ophthalmologists, identified through professional electronic networks or previous publications, collected standardized clinical data relating to 62 eyes of 49 patients who...

purpose: to report complications involving the posterior segment after laser assisted in situ keratomileusis (lasik) in 5 myopic patients ranging in age from 26 to 38 years. patients and findings: case one developed bilateral cilioretinal artery obstruction in association with ischemic optic neuropathy. case two presented with nonsimultaneous bilateral delayed-onset optic neuropathy. in case th...