by Activation of Sarcolemmal but not Mitochondrial ATP-Sensitive Potassium Channels in Mice To the Editor: Recently, Suzuki et al1 reported that attenuation of myocardial stunning by diazoxide in mice was mediated through activation of sarcolemmal rather than mitochondrial K ATP channels. Although the authors used an elegant approach by combining both pharmacological tools (utilizing the mitoch...

Recent studies suggest that the hydroxyl radical (-OH) plays a pathogenetic role in postischemic ventricular dysfunction (myocardial "stunning"). This concept, however, is predicated exclusively on results obtained in anesthetized open-chest preparations, which are subject to the confounding influence of many unphysiological conditions and in which both myocardial stunning and free radical gene...

UNLABELLED Chronic ingestion of small doses of ethanol protects the myocardium from ischemic damage. It was demonstrated that short-term administration of ethanol (SAE) enhances the recovery of stunned myocardium in acutely instrumented, anesthetized dogs. It is unclear whether this beneficial effect of SAE also occurs in awake dogs. Therefore, we investigated the effects of SAE on regional myo...

Postconditioning, i.e., brief intermittent episodes of myocardial ischemia-reperfusion performed at the onset of reperfusion, reduces infarct size after prolonged ischemia. Our goal was to determine whether postconditioning is protective against myocardial stunning. Accordingly, conscious chronically instrumented dogs (sonomicrometry, coronary balloon occluder) were subjected to a control seque...

Abstract Background Takotsubo syndrome (TS) and ST-elevation myocardial infarction (STEMI) are both characterized by sudden cessation of contractions (myocardial stunning) as well elevation cardiac troponins B-type natriuretic peptides (BNP). Whereas STEMI results in variable degrees necrosis persistent dysfunction, TS little to any full recovery function. No “head-to-head” comparison the tempo...