نتایج جستجو برای: one clip hypertension

تعداد نتایج: 2140825  

Journal: :Hypertension 1985
P B Furspan D F Bohr

Lymphocyte number and weight and their sodium and potassium contents and net passive fluxes were measured in spontaneously hypertensive stroke-prone rats, deoxycorticosterone acetate-treated rats, and two-kidney, one clip renal hypertensive rats. Wistar-Kyoto rats were used as controls for the spontaneously hypertensive stroke-prone rats, and normal intact Sprague-Dawley rats were used as contr...

2010
Elizabeth B. Oliveira-Sales Débora S.A. Colombari Robin L. Davisson Sergey Kasparov Aparecida E. Hirata Ruy R. Campos Julian F.R. Paton

Reactive oxygen species in peripheral cardiovascular tissues are implicated in the pathogenesis of 2 kidney-1 clip hypertension. We recently identified an imbalance between reactive oxygen species generation and oxidant scavenging in the rostral ventrolateral medulla (RVLM) of 2 kidney-1 clip in rats. We tested whether enhanced superoxide signaling in RVLM of 2 kidney-1 clip rats contributes to...

2005
Michael Bohm Peter Gierschik Andreas Knorr Katharina Larisch Korinna Weismann

The present study investigated whether reduced adenylate cyclase activity and an increase in inhibitory guanine nucleotide binding proteins (G^), which have been observed in the failing human heart, already occur in myocardial hypertrophy before the stage of heart failure. In membranes of hypertrophic hearts from rats with different forms of experimentally induced hypertension without heart fai...

Journal: :Nihon Naibunpi Gakkai zasshi 1982
K Mizuno M Gotoh T Toki J Matsui S Fukuchi

Angiotensin-converting enzyme activity of the aortic subcellular fractions (homogenate, mitochondria, microsomes and supernatant) was determined in normotensive and experimental hypertensive rats (1-clip, 1-kidney Goldblatt hypertensive; 1-clip, 2-kidney Goldblatt hypertensive and 2-clip, 2-kidney hypertensive rats). The systolic blood pressure markedly elevated in each group of experimental hy...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2007
Oliver Jung Stefan L Marklund Ning Xia Rudi Busse Ralf P Brandes

OBJECTIVES Extracellular superoxide dismutase (ecSOD) lowers superoxide anions and maintains vascular nitric oxide level. We studied the function of ecSOD in high-volume hypertension induced by the 1-kidney-1-clip model in wild-type, ecSOD-/- mice, and endothelial nitric oxide synthase (eNOS)-/- mice. METHODS AND RESULTS The 1-kidney-1-clip model resulted in impaired endothelium-dependent rel...

Journal: :Lancet 1970
W J Louis G J Macdonald V Renzini G W Boyd W S Peart

The rabbit immunized against angiotensin II was shown to be a valid model for the study of renal-clip hypertension. In particular, there was a specific and complete blockade of the pressor effect of high doses of intravenous renin and angiotensin in vivo, even at angiotensin II production rates which far exceeded those associated with renal-clip hypertension. Despite this, four immunized rabbit...

2008
Ying Sun Oscar A. Carretero Jiang Xu Nour-Eddine Rhaleb James J. Yang Patrick J. Pagano Xiao-Ping Yang

Inducible NO synthase (iNOS) has been implicated in the pathogenesis of hypertension and target organ damage. We hypothesized that induction of iNOS contributes to left ventricular (LV) hypertrophy and dysfunction in mice with 2-kidney, 1-clip hypertension. Deletion of iNOS diminishes oxidative stress, thereby attenuating LV hypertrophy and enhancing cardiac performance. 2-Kidney, 1-clip hypert...

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