The purpose of the present investigation is to assess the influence of casting solvent on crystallinity of ondansetron hydrochloride in transdermal polymeric matrix films fabricated using povidone and ethyl cellulose as matrix forming polymers. Various casting solvents like chloroform (CHL), dichloromethane (DCM), methanol (MET); and mixture of chloroform and ethanol (C-ETH) were used for fabri...

PURPOSE A virtual screening study has suggested that the skeletal muscle relaxant, dantrolene, and the antiemetic drug, ondansetron, may act as inhibitors of the enzyme acetylcholinesterase (AChE). Based on this proposal, the current study examines the AChE inhibitory properties of these drugs. METHODS AND FINDINGS Using AChE from human erythrocytes as enzyme source, it is shown that dantrole...

background: nausea and vomiting are common complications of anesthesia and surgery. patients undergoing tympanoplasty are exposed to a higher risk of postoperative nausea vomiting (ponv). these complications may alter the results of reconstruction and anatomical alignments. numerous antiemetics have been studied to prevent and treat ponv in patients undergoing tympanoplasty. the aim of this stu...

postoperative nausea and vomiting (ponv) are one of the most common complications of anesthesia and without prophylactic intervention occurs by about one-third of patients under general anesthesia. the aim of this study was to compare the efficacy of ondansetron and metoclopramide in reducing ponv after laparoscopic cholecystectomy. in this study, 60 patients undergoing laparoscopic cholecystec...

background the involved neurotransmitter pathways in the postoperative shivering (pos) are poorly understood. recently, 5-hydroxytryptamine 3 (5-ht3) receptor antagonists have been reported to prevent pos. we investigated the effect of ondansetron, a 5-ht3 antagonist that is used to treat postoperative nausea and vomiting, on shivering. objectives this study aimed to compare the efficacy of ond...

The effect of pretreatment with odansetron on prolactin (PRL) release induced by electroconvulsive therapy (ECT) was examined in 16 depressive patients in a double-blind, placebo-controlled crossover study. Ten patients were pretreated with 4 mg and the other six with 8 mg of ondansetron. The order of administration of study medication (ondansetron and placebo) was counterbalanced. The failure ...

Ondansetron is widely believed to prevent postoperative vomiting more effectively than nausea. We analysed data from 5161 patients undergoing general anaesthesia who were randomly stratified to receive a combination of six interventions, one of which was 4 mg ondansetron vs placebo. For the purpose of this study a 20% difference in the relative risks for the two outcomes was considered clinical...

The cost effectiveness of ondansetron was compared with that of metoclopramide in the prevention of acute emesis due to highly emetogenic chemotherapy in an open, randomised, parallel group pilot study. Ondansetron was given as three 8 mg intravenous doses (0, 4 and 8 h) and metoclopramide as an intravenous loading dose (3 mg/kg) followed by a maintenance dose of 0.5 mg/kg/h for 8 h. Therapeuti...

This prospective, randomized, double-blinded, placebo-controlled study in which 150 ASA I-II patients scheduled for middle ear surgery were randomized into three equal groups. The dexamethasone group (group D) received a single dose of dexamethasone 10 mg IV at induction of anesthesia, ondansetron group (group O) received 4 mg IV ondansetron and the control group (group C) received 5 ml saline ...

Recent studies have shown that aprepitant, a substance – P/ Nk 1 receptor antagonist is effective in postoperative vomiting. The present study was designed to find out whether addition of aprepitant to ondansetron would be more effective than ondansetron alone in prevention of post operative nausea and vomiting in patients undergoing laparoscopic surgeries. After obtaining informed consent, 50 ...