نتایج جستجو برای: oligonucleotide array sequence analysis
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Background: Malignant melanoma is a highly metastatic cutaneous cancer and typically refractory to chemotherapy. Deregulated apoptosis has been identified as a major cause of cancer drug resistance, and upregulated expression of the inhibitor of apoptosis protein melanom, an inhibitor of apoptosis (ML-IAP) is frequent in melanoma. Methods: Based on the conclusion that ML-IAP expression contribu...
Motivation: Various tasks in computational biology, including primer and oligonucleotide array design; epitope mapping, etc. require finding unique regions in gene sequences. We developed a novel algorithm that finds such unique regions based on an alignment of the gene sequence to its paralogs. This algorithm was utilized for in-silico expression profiling using EST databases – an accurate low...
Let be a sequence of arbitrary random variables with and , for every and be an array of real numbers. We will obtain two maximal inequalities for partial sums and weighted sums of random variables and also, we will prove complete convergence for weighted sums , under some conditions on and sequence .
The detection of copy number variants (CNV) by array-based platforms provides valuable insight into understanding human diversity. However, suboptimal study design and data processing negatively affect CNV assessment. We quantitatively evaluate their impact when short-sequence oligonucleotide arrays are applied (Affymetrix Genome-Wide Human SNP Array 6.0) by evaluating 42 HapMap samples for CNV...
Most of the recent developments in ultrasensitive detection of nucleic acid are based on the gold nanoparticles and carbon nanotubes as a medium of signal amplification. Here, we present an ultrasensitive electrochemical nucleic acid biosensor using the conducting polyaniline (PANI) nanotube array as the signal enhancement element. The PANI nanotube array of a highly organized structure was fab...
BACKGROUND Submicroscopic genomic imbalance underlies well-defined microdeletion and microduplication syndromes and contributes to general developmental disorders such as mental retardation and autism. Array comparative genomic hybridization (CGH) complements routine cytogenetic methods such as karyotyping and fluorescence in situ hybridization (FISH) for the detection of genomic imbalance. Oli...
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